Zolppi DSR Tablet


Each ZOLPPI-DSR tablet contains rabeprazole 20mg and domperidone 10mg.


ZOLPPI-DSR tablet is an anti-ulcerant and anti-emetic combination of domperidone and rabeprazole. Rabeprazole is a proton pump inhibitor, while domperidone is a dopamine antagonist. This combination treats acid-reflux issues, different types of ulcers, nausea and vomiting. The combination of rabeprazole and domperidone is observed to address gastroesophageal reflux disorder effectively, than rabeprazole alone.

Rabeprazole, which is a substituted benzimidazole, works as a proton pump inhibitor (PPI). Rabeprazole is activated in the acidic environment only. Rabeprazole gets absorbed by the parietal cells. After the activation, this drug binds to the H+/ K+ ATPase system present on the parietal cells and blocks the inward movement of H+ ions into the stomach and prevents the last step of acid production.

Domperidone is a strong anti-emetic and anti-ulcerant agent that controls nausea and vomiting along with the suppression of acid-reflux. On peripheral levels, it increases the lower esophageal pressure, improves the motility in the upper GI tract or peristalsis. Centrally, domperidone acts as an antagonist of D2 and D3 dopamine receptors in the area postrema of the brain where the chemoreceptor trigger zone for nausea and vomiting is present.


  • Helicobacter pylori infection and eradication
  • Heartburn
  • Gastroesophageal Reflux Disease (GERD)
  • Non-erosive Reflux Disease (NERD)
  • Zollinger-Ellison Syndrome
  • Duodenal and gastric ulcers
  • Intractable nausea and vomiting

Dosage and Administration:

As directed by the physician


ZOLPPI-DSR tablets are contraindicated in patients with hypersensitivity towards rabeprazole and domperidone. It is also contraindicated in patients with electrolyte disturbances, congestive heart failure, hepatic disorders, renal disorders and gastrointestinal hemorrhage.

Adverse effects:

Adverse effects of this medicine include nausea, pruritus, abdominal pain, insomnia, constipation, headache, diarrhea and rashes


There are no sufficient and well-controlled studies when it comes to rabeprazole and domperidone administration in pregnant women and nursing mothers. Therefore, if you are pregnant or nursing, discuss with your doctor about your condition before taking this medicine.


ZOLPPI DSR capsules are available in 10X10’s Alu Alu packing.


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Keep the medicines out of the children’s reach. This product is to be stored as recommended. Do not exceed the recommended dosage. Do not use this information in place of a visit, consultation or advice of your healthcare providers.