Each ZOLPPI-D tablet contains rabeprazole 20mg and domperidone 10mg.
ZOLPPI-D tablet is an anti-ulcerant and anti-emetic combination that addresses acid-reflux issues, different types of ulcers, nausea and vomiting. Rabeprazole is a proton pump inhibitor, while domperidone is a dopamine antagonist. Studies show that the combination of rabeprazole and domperidone effectively addresses gastroesophageal reflux disorder than rabeprazole alone.
Rabeprazole is a substituted benzimidazole and it works as a proton pump inhibitor (PPI). After the administration, rabeprazole is absorbed by the parietal cells. Rabeprazole is activated in the acidic environment only. The activated rabeprazole binds to the H+/ K+ ATPase system present on the parietal cells and prevents the inward movement of H+ ions into the stomach and inhibits the gastric acid production.
Domperidone is a strong anti-emetic and anti-ulcerant agent that controls nausea and vomiting along with the suppression of acid-reflux. On peripheral levels, it increases the lower esophageal pressure, improves the motility in the upper GI tract or peristalsis. Centrally, domperidone acts as an antagonist of D2 and D3 dopamine receptors in the area postrema of the brain where the chemoreceptor trigger zone for nausea and vomiting is present.
As directed by the physician
ZOLPPI-D tablets are contraindicated in patients with hypersensitivity towards rabeprazole and domperidone. It is also contraindicated in patients with electrolyte disturbances, congestive heart failure, hepatic disorders, renal disorders and gastrointestinal hemorrhage.
Adverse effects of this medicine include nausea, pruritus, abdominal pain, insomnia, constipation, headache, diarrhea and rashes
There are no sufficient and well-controlled studies when it comes to rabeprazole and domperidone administration in pregnant women and nursing mothers. Therefore, if you are pregnant or nursing, discuss with your doctor about your condition before taking this medicine.
ZOLPPI D tablets are available in 10X10’s Alu Alu packing.
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Keep the medicines out of the children’s reach. This product is to be stored as recommended. Do not exceed the recommended dosage. Do not use this information in place of a visit, consultation or advice of your healthcare providers.