Each VOMIDIS-O tablet contains ondansetron 4mg and omeprazole 20mg.


VOMIDIS-O is an anti-emetic and anti-ulcerant combination of ondansetron and omeprazole. This combination effectively addresses different types of ulcers, acid reflux disorders and nausea and vomiting associated with radiotherapy and chemotherapy.

Ondansetron is a synthetic drug that belongs to the class of serotonin 5-HT3 receptor antagonists. Nausea and vomiting is a natural reflux that is observed in patients who are undergoing chemo and radiotherapies because of drug combinations and high drug doses. The neurotransmitter, serotonin plays a key role in triggering nausea and vomiting and ondansetron works by suppressing the activity of serotonin. 5-HT receptors - the receptors that are associated with nausea and vomiting, are found in the chemoreceptor trigger zone (CTZ) of the central nervous system and at the vagal nerve terminals in the intestine of the peripheral nervous system. Ondansetron specifically blocks these receptors and prevents the vomiting reflux.

Omeprazole is a proton pump inhibitor that blocks the influx of H+ ions into the stomach and prevents the gastric acid secretion. This drug blocks the activity of H+/ K+ ATPase system present on the parietal cells of the inner lining of the stomach and suppresses the levels of the stomach acid.


  • Abdominal pain
  • Dyspepsia
  • Heartburn
  • Erosive gastritis
  • Zollinger-Ellison syndrome
  • Gastroesophageal reflux disease
  • Stomach and intestinal ulcers
  • Nsaid-induced ulcers
  • Nausea and vomiting caused by chemotherapy or radiotherapy

Dosage and Administration:

As directed by the physician


VOMIDIS-O tablets are contraindicated in patients with hypersensitivity towards ondansetron and omeprazole. It is also contraindicated in patients with gastric malignancy, hepatic impairment and renal impairment.

Adverse effects:

Adverse effects of this medicine include a headache, GI disturbances, nausea, increased levels of liver enzymes, abdominal pain, constipation, diarrhea, rashes due to allergy, gas, uneven heartbeats, hypotension and unusual tiredness.


People with known prior health conditions should talk to their physician before taking this medicine.


VOMIDIS-O tablets are available in 10X10’s Alu Alu packing.


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Keep the medicines out of the children’s reach. This product is to be stored as recommended. Do not exceed the recommended dosage. Do not use this information in place of a visit, consultation or advice of your healthcare providers.