Simgesic D


Each SIMGESIC-D tablet contains serratiopeptidase 10mg and diclofenac sodium 50mg.


SIMGESIC-D is an anti-inflammatory and analgesic combination of a non-steroidal anti-inflammatory drug, diclofenac and a proteolytic and fibrinolytic agent, serratiopeptidase. This combination can be used to treat joint inflammation, post-operative pain, swelling, inflammation of the respiratory tract and migraine.

Diclofenac sodium is a drug with strong anti-inflammatory and analgesic properties. Diclofenac blocks the leukocyte migration and the activity of the enzyme - cyclooxygenase (COX-1 and COX-2). Cyclooxygenase or the prostaglandin synthetase is the enzyme that converts arachidonic acid to prostaglandins, leukotrienes and other inflammatory mediators. These inflammatory mediators are associated with pain and swelling and suppressing their production, will relieve the pain.

Serratiopeptidase is an enzyme that is derived from the bacterium, Serratia sp. E-15.Serratiopeptidase hydrolyzes histamines, cytokines, bradykinin and serotonin and eventually reduces the pain and swelling that are associated with the inflammation.


  • Joint pain
  • Lower back pain
  • Bone fractures
  • Joint inflammation
  • Pain and swelling associated with the surgeries
  • Migraine
  • Laryngitis
  • Pharyngitis
  • Sore throat
  • Ear infection
  • Thrombophlebitis

Dosage and Administration:

As directed by the physician


SIMGESIC-D tablets are contraindicated in patients with hypersensitivity towards diclofenac sodium and serratiopeptidase. It is also contraindicated in patients with hepatic impairment, renal impairment, asthma and urticaria.

Adverse effects:

Adverse effects of this medicine include upset stomach, epigastric pain, diarrhea, constipation, nausea, vomiting, GI bleeding, shortness of breath, redness of the skin, liver damage, blisters and toxic epidermal necrolysis.


There are no sufficient and well-controlled studies when it comes to diclofenac and serratiopeptidase administration in pregnant women and nursing mothers. Therefore, if you are pregnant or nursing, discuss with your doctor about your condition before taking this medicine.


SIMGESIC-D tablets are available in 10X10’s blister packing.


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Keep the medicines out of the children’s reach. This product is to be stored as recommended. Do not exceed the recommended dosage. Do not use this information in place of a visit, consultation or advice of your healthcare providers.