Each NOLL CF tablet contains cefixime trihydrate IP (equivalent to anhydrous cefixime) 200mg and ofloxacin IP 200mg.
NOLL CF is the brand name for the antibiotic combination of cefixime, a third generation cephalosporin antibiotic and ofloxacin, a fluoroquinolones antibiotic. NOLL CF exhibits broad-spectrum activity, with a longer half-life and higher penetrability. This combination treats major bacterial infections such as ear-nose-throat infections, upper respiratory tract infections and genitourinary tract infections.
Cefixime is one of the very few antibiotics that are stable against cephalosporinase and beta-lactamase activity. Cefixime is the beta-lactam antibiotic that works by inhibiting the cell wall synthesis in the bacterial cells. This drug binds to specific penicillin-binding proteins (PBPs), which control the transpeptidation step of peptidoglycan synthesis. This binding between the PBPs and beta-lactam ring of cefixime prevents the cell wall synthesis, eventually leading to the bacterial cell death.
Ofloxacin is a synthetic antibiotic that belongs to the class of second-generation fluoroquinolones. It acts on the DNA gyrase and topoisomerase IV enzymes that are associated with the DNA replication in bacteria. By binding to these enzymes, ofloxacin hampers the unwinding and supercoiling properties of these enzymes and eventually arrest the cell growth in bacteria.
As directed by the physician
NOLL CF tablet is contraindicated in patients with hypersensitivity towards cefixime and ofloxacin. This medicine is also contraindicated in patients with epilepsy, Clostridium difficile infection, myasthenia gravis, renal insufficiency and seizures.
Adverse effects of this medicine include abdominal pain, nausea, vomiting, severe itching of skin, insomnia, dizziness, emesis, dyspepsia, headache, diarrhea, eosinophilia, hallucination and sinus tachycardia.
There are no sufficient and well-controlled studies when it comes to cefixime and ofloxacin administration in pregnant women and nursing mothers. Therefore, if you are pregnant or nursing, discuss with your doctor about your condition before taking this medicine.
NOLL CF tablets are available in 10X10’s Alu Alu packing.
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