Each tablet of NEVIMOX-SB 1000 contains amoxicillin 500mg and sulbactam 500mg.
NEVIMOX-SB 1000 is the brand name for the antibiotic combination of amoxicillin and the beta-lactamase inhibitor, sulbactam. This oral medication is effective against the broad spectrum of micro-organisms. NEVIMOX-SB 1000 works by preventing the cell wall synthesis and is bactericidal in nature.
Amoxicillin belongs to the class of aminopenicillins and is a beta-lactam antibiotic. Like other beta-lactam antibiotics, this drug binds to specific Penicillin Binding Proteins (PBPs) that are present within the cell envelope of the bacterial cells. The penicillin-sensitive transpeptidase-C terminal domain of the PBPs is acylated by the amoxicillin and the domain becomes inactivated. This leads to the inhibition of cross-linkage between the linear peptidoglycan polymer chains, which in turn lead to bacterial cell death. Amoxicillin is not resistant to beta-lactamase activity and is prone to ready degradation by the enzyme. Therefore, it has to be administered with beta-lactamase inhibitors like sulbactam.
Sulbactam is an effective beta-lactamase inhibitor, whose function is to prevent the degradation of amoxicillin by the beta-lactamase enzyme present within the bacterial cell wall. Like amoxicillin, sulbactam also possesses a beta-lactam ring which binds to the beta-lactamase enzyme and prevents the enzyme’s binding to the beta-lactam ring of the antibiotic, amoxicillin.
As directed by the physician
NEVIMOX-SB 1000 tablets are contraindicated in patients with hypersensitivity towards its ingredients and penicillins. It is also contraindicated in patients with hepatic impairment, renal impairment and Clostridium difficile bacterial infection.
Adverse effects of this medication are nausea, vomiting, diarrhea, chest pain, painful urination, impaired liver functions, loss of appetite, abdominal pain, sore throat and body aches.
NEVIMOX-SB 1000 tablets are available in 10X10’s Alu Alu packing.
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