Fexofenadine is an active metabolite of terfenadine, is a second-generation, long lasting H1-receptor antagonist which has a selective and peripheral H1-antagonistic action. Fexofenadine blocks the H1-receptor and thus prevents activation of cells by histamine in the GI tract, large blood vessels and bronchial smooth muscle. This leads to relief of the allergic symptoms.
Montelukast is a selective and orally active leukotriene receptor antagonist that inhibits the cysteinyl leukotriene CysLT1 receptor. Cysteinyl leukotrienes and leukotriene receptor occupation have been correlated with the pathophysiology of asthma ( such as, airway edema, smooth muscle contraction and altered cellular activity associated with the inflammatory process, which contribute to the signs and symptoms of asthma).
Asthma, chronic allergy, seasonal allergy, hay fever.
As directed by the physician.
Hypersensitivity, patients with blood and lymphatic system disorder and psychiatric disorder.
Patients with known aspirin sensitivity should continue avoidance of aspirin or other NSAID, while taking Montelukast.
Montelukast is not indicated for use in the reversal of bronchospasm in acute asthma attacks
The most commonly reported adverse events are headache, drowsiness, nausea, and dizziness, viral infection (cold/flu),dizziness, fatigue; nausea, dyspepsia, dysmenorrhoea.
For montelukast, there is limited human data available. It is most likely compatible.
There are no controlled data in human pregnancy. Fexofenadine is only recommended for use during pregnancy when benefit outweighs risk.
FEXODIS-M tablets are available in a 10X10ís strip packing
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