ESOZEL-D Capsule

Esomeprazole sodium-ESOZEL-D Capsule


Each hard gelatin capsule of ESOZEL-D capsule contains:

  • Esomeprazole sodium equivalent to esomeprazole 40mg.
  • Domperidone HCl SR (as sustained release capsule) 30mg.


ESOZEL-D is the brand name for the anti-ulcerant and antiemetic formulation of esomeprazole and domperidone. This combination effectively treats acid reflux-related disorders.

Esomeprazole is one of the major anti-ulcerants that belong to the class of the substituted benzimidazoles. Esomeprazole is a proton pump inhibitor, which prevents the final step of gastric acid formation i.e., the influx of H+ ions into the stomach. The proton pump system or the H+/ K+ ATPase enzyme system are found on the parietal cells, which are the highly specialized epithelial cells present in the stomach’s inner lining. Esomeprazole binds to the proton pump systems and prevents the acid formation in the stomach. Domperidone works as a GI emptying agent and a peristaltic stimulant. Its prokinetic properties come from its peripheral dopamine receptor blocking activities. This drug empties the GI tract and reduces the bowel transit time effectively by reducing the pressure on esophageal sphincter and increasing peristalsis along the GI tract. Domperidone has a high affinity for D2 and D3 dopamine receptors and regulates nausea and vomiting.


  • Acid reflux
  • Peptic and gastric ulcers
  • Heartburn
  • Difficulty in swallowing
  • Gastroesophageal reflux disease (GERD)
  • Dyspepsia
  • Upper gastrointestinal motility disorders
  • Diabetic gastroparesis
  • Nausea and vomiting
  • Helicobacter pylori infection
  • Zollinger-Ellison syndrome

Dosage and Administration:

As directed by the physician


Do not crush or chew this medicine. ESOZEL-D capsule should be swallowed as a whole.


ESOZEL-D is contraindicated in patients with hypersensitivity towards esomeprazole and domperidone. It is also contraindicated in patients with cardiac disorders, renal impairment, hepatic impairment, significant electrolyte disturbances, prolactinoma, gastrointestinal bleeding, bowel impairment and Parkinson's disease.

This medicine is not recommended for children who are less than 12 years old.

Adverse Effects:

Adverse effects of this medicine include diarrhea, dry mouth, galactorrhoea , gynaecomastia, skin rash, abdominal discomfort, dystonic reactions, nausea, abdominal, pain, constipation, headache and flatulence. Precaution:

There are no sufficient and well-controlled studies when it comes to esomeprazole and domperidone administration in pregnant women and nursing mothers. Therefore, if you are pregnant or nursing, discuss with your doctor about your condition before taking this medicine.


ESOZEL-D capsules are available in 10X10’s Alu Alu packing.


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Keep the medicines out of the children’s reach. This product is to be stored as recommended. Do not exceed the recommended dosage. Do not use this information in place of a visit, consultation or advice of your healthcare providers.