Each film-coated DOXPORIN CV tablet contains anhydrous cefpodoxime 200mg and diluted potassium clavulanate (eq to clavulanic acid) 125mg.
DOXPORIN-CV is the brand name for the antibiotic combination of clavulanic acid and cefpodoxime. Cefpodoxime is a beta-lactam antibiotic that belongs to the class of third-generation cephalosporins. Clavulanic acid is a beta-lactamase inhibitor whose prime function is to protect the antibiotic activity of cefpodoxime.
Cefpodoxime works by inhibiting the cell wall synthesis in bacteria. This drug binds to the Penicillin Binding Protein 3 and blocks the transpeptidation step of peptidoglycan synthesis in bacteria. The transpeptidation step is crucial for the cross-linking in the bacterial cell wall, and without this cross-linkage, the bacterial cells cannot hold their content within them. This leakage will eventually lead to the death of the bacterial cells. Cefpodoxime is stable against the activity of penicillinases, cephalosporinases and different beta-lactamases.
Clavulanic acid, which also possesses a beta-lactam ring binds to the beta-lactamase enzyme of the bacteria, when administered along with cefpodoxime and thereby prevents the binding of the beta-lactamase enzyme to cefpodoxime. Cefpodoxime is susceptible to degradation by a few beta-lactamases and clavulanic acid prevents this interaction. Cefpodoxime in combination with clavulanic acid is effective against several Gram +ve and Gram-ve bacteria.
As directed by the physician
DOXPORIN CV tablet is contraindicated in patients with hypersensitivity towards cefpodoxime and clavulanic acid, Clostridium difficile infection, hepatic impairment, renal impairment and seizure disorders
Adverse effects of this medicine include GI disturbances, nausea, vomiting, diarrhea, rashes and itching.
There are no sufficient and well-controlled studies when it comes to cefpodoxime and clavulanic acid administration in pregnant women and nursing mothers. Therefore, if you are pregnant or nursing, discuss with your doctor about your condition before taking this medicine.
DOXPORIN CV tablets are available in 10X1X6's Alu Alu packing.
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