DOBEX S 1500 consists of ceftriaxone 1000mg and sulbactam 500mg.
DOBEX S 1500 is the brand name antibiotic combination of a beta-lactam antibiotic, ceftriaxone and the beta-lactamase inhibitor, sulbactam. This combination is resistant to cephalosporinases, penicillinases and beta-lactamases activity. It exhibits broad-spectrum activity against gram +ve and gram –ve bacteria.
The beta-lactam ring of ceftriaxone binds to the penicillin-binding proteins (PBPs) present in the cell wall and inhibits the transpeptidation step of the peptidoglycan synthesis in bacteria. The transpeptidation step is crucial for the cross-linking in the bacterial cell wall. If this step is inhibited, it leads to leakage of the cellular contents and death of the bacterial cells.
Sulbactam is a beta-lactamase inhibitor, which prevents the degradation of ceftriaxone. Sulbactam’s structure also has a beta-lactam ring, which binds to the beta-lactamase enzyme in the bacteria. This interaction prevents the binding of the enzyme, beta-lactamase to the beta-lactam ring of ceftriaxone and this allows the antibiotic ceftriaxone inhibit the bacterial growth without being degraded.
This medicine has to be administered under medical supervision only.
DOBEX S 1500 is contraindicated in patients with hypersensitivity towards ceftriaxone, sulbactam and other cephalosporins. This medicine is also contraindicated in patients with hemolytic anemia, hepatic disorders, Clostridium difficile infections and kidney diseases.
Adverse effects of this medicine include, nausea, vomiting, GI disturbances, pain and swelling in the tongue, headache, and vaginal itching and discharge.
There are no sufficient and well-controlled studies when it comes to ceftriaxone and sulbactam administration in pregnant women and nursing mothers. Therefore, if you are pregnant or nursing, discuss with your doctor about your condition before taking this medicine.
DOBEX S 1500 injection is available in Vial with WFI with outer carton pack.
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