Dobex 500 Injection


Ceftriaxone 500mg


DOBEX 500 is the brand name for the beta-lactam antibiotic-ceftriaxone. Ceftriaxone is the third generation cephalosporin drug that works by interfering with the cell wall synthesis in bacteria. It is effective against several gram +ve bacteria, due to its high penetrability and longer half-life. This drug is resistant to beta-lactamase, penicillinases and cephalosporinases activity.

Mechanism of Action:

Ceftriaxone, which has a beta-lactam ring, binds to the penicillin-binding proteins (PBPs) present in the bacterial cell wall. This binding is followed by a series of reactions, and ultimately the transpeptidation step is blocked. This leads to the leakage of the cell contents and ultimately causes to the death of the bacterial cells.


  • Community-acquired pneumonia
  • Congenital gonococcal conjunctivitis
  • Endocarditis
  • Gonorrhea
  • Lyme disease
  • Meningitis
  • Otitis Media
  • Pelvic inflammatory disease
  • Skin/ skin-structure infections
  • Syphilis
  • Typhoid fever
  • Post operative infections
  • Prosthetic joint infections
  • Lower respiratory tract infections
  • Epiglottitis

Dosage and Administration:

This medicine has to be administered under medical supervision only.


DOBEX 500 is contraindicated in patients with hypersensitivity towards ceftriaxone, hemolytic anemia, hepatic disorders, Clostridium difficile infections and kidney diseases.

Adverse Effects:

Adverse effects of this medicine include, nausea, vomiting, GI disturbances, pain and swelling in the tongue, headache, and vaginal itching and discharge.


There are no sufficient and well-controlled studies when it comes to ceftriaxone administration in pregnant women and nursing mothers. Therefore, if you are pregnant or nursing, discuss with your doctor about your condition before taking this medicine.


DOBEX 500 injection is available in Vial with WFI with outer carton pack.


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Keep the medicines out of the children’s reach. This product is to be stored as recommended. Do not exceed the recommended dosage. Do not use this information in place of a visit, consultation or advice of your healthcare providers.