Each CLINDIS-CZ softgel capsule contains clindamycin phosphate 100mg and clotrimazole 200mg.
CLINDIS-CZ is the vaginal capsule designed for the treatment of vulvovaginal infections caused due to bacteria and fungi. Clindamycin is a potent antibacterial agent, while clotrimazole is a broad spectrum antifungal agent. This combination works by stopping the growth of bacterial and fungal cells. This combination reduces the burning and itching sensation along with the abnormal vaginal discharge.
Clindamycin is lincosamide antibiotic of semi-synthetic origin with least side effects. Clindamycin works by inhibiting the protein synthesis in the bacterial cells. This drug specifically binds to the 23S RNA subunit of 50S ribosomal subunit to block the polypeptide exit tunnel and thereby prevents the peptide chain elongation. Protein synthesis is crucial for the survival of the bacterial cells and this being blocked, leads to the reduced bacterial growth. Clindamycin is bacteriostatic in action.
Clotrimazole is an imidazole derivative with both fungicidal and fungistatic properties. This drug works by interfering with the cell wall synthesis in the fungal cells. Clotrimazole blocks the synthesis of ergosterol, which is the key constituent of fungal and protozoan cells. Clotrimazole binds to 14-a demethylase, a cytochrome P-450 enzyme that converts lanosterol to ergosterol and inhibits its activity. Blocking of the ergosterol synthesis leads to the increased membrane permeability, which eventually leads to the death of the fungal and protozoan cells.
One capsule should be inserted in the vagina, for 3 consecutive days at the bed time. Treatment should be timed as to avoid the menstrual period.
CLINDIS-CZ softgels are contraindicated in patients who are hypersensitive to clindamycin and clotrimazole. It is also contraindicated in patients with blood dyscrasias, decreased neutrophils and epileptic seizures.
Adverse effects of this medicine are stinging, erythema, burning, vesication, desquamation, burning, peeling and irritation.
There are no sufficient and well-controlled studies when it comes to the usage of clindamycin and clotrimazole vaginal capsules in pregnant women and nursing mothers. Therefore, if you are pregnant or nursing, discuss with your doctor about your condition before taking this medicine.
CLINDIS-CZ softgel capsules are available in 20X1X3's blister packing.
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