CEFTADIS TB injection contains Ceftazidime 1000mg and Tazobactam 125mg
CEFTADIS TBis a powerful antibiotic combination ofceftazidime and tazobactam. The key function of ceftazidime is to prevent the synthesis of cell wall in the bacteria and the function of tazobactam is to prevent the destruction of the ceftazidime by the chemicals released from the bacteria.
Ceftazidime belongs to the class of third generation cephalosporins. Ceftazidime effectively acts against several Gram+ve and Gram-ve bacteria. This drug, unlike other third generation cephalosporins, can also act against Pseudomonas aeruginosa. Ceftazidime prevents the cell wall synthesis in bacteria by binding to the penicillin-binding proteins (PBPs) that are present within the bacterial cell. This binding inhibits the transpeptidation step of peptidoglycan synthesis phenomenon, which eventually prevents the cell wall assembly and leads to death of the bacterial cells.
Tazobactam works by inhibiting the beta-lactamase activity in the bacterial cells. The chemical composition of tazobactam contains a heavily modified penicillin molecule combined with sulfone. This drug has a key role in protecting the antibacterial activity of ceftazidime. The beta-lactam ring of tazobactam interacts with beta-lactamase enzyme present within the bacteria and prevents the degradation of ceftazidime. Apart from this, tazobactam also exhibits moderate antimicrobial activity against Acinetobacter spp. and Borreliaburgdorferi according to a few reports.
This medicine has to be administered under medical supervision only.
CEFTADIS TBinjection is contraindicated in patients with hypersensitivity towards its ingredients and other cephalosporins and penicillins. It is also contraindicated in patients with hepatic impairment, pseudomembranous colitis, seizures and Clostridium difficile bacterial infection.
Adverse effects of this medication are injection site inflammation, rashes, fever, diarrhea, nausea, headache, dizziness, constipation, indigestion and pain.
There are no sufficient and well-controlled studies when it comes to ceftazidime administration in pregnant women and nursing mothers. Therefore, if you are pregnant or nursing, discuss with your doctor about your condition before taking this medicine.
CEFTADIS-TB injection is available in 5x1mL Tray pack
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