Exploring the Benefits of Clobetasol Propionate-0.05%, Miconazole Nitrate-2% and Neomycin-0.5% Cream

Indications for cream with combination of Clobetasol, Miconazole and Neomycin

When it comes to dermatological conditions, finding an effective treatment can be a challenging task. Clobetasol, Miconazole, and Neomycin cream (0.05%, 2%, and 0.5% respectively) provide a potent solution, protecting the skin from bacterial and fungal infections.

This cream, containing Clobetasol Propionate (0.05%), Miconazole Nitrate (2%), and Neomycin (0.5%), treats skin infections and inflammation, including bacterial or fungal complications. It helps in managing the symptoms like scratching, red sores, itching and rashes when associated with skin infections.

Understanding the Pharmaceutical Active Ingredients:

Clobetasol Propionate (0.05%):

Additionally, Clobetasol Propionate, a topical corticosteroid, exhibits anti-inflammatory, antipruritic, and vasoconstrictive properties. Furthermore, it alleviates redness, itching, and swelling associated with skin conditions such as eczema, psoriasis and allergic reactions. By targeting the underlying inflammation, Clobetasol Propionate provides effective short-term relief for localized inflammation.

Miconazole Nitrate (2%):

Miconazole Nitrate is an imidazole antifungal agent that disrupts the permeability of fungal cell membranes. It inhibits the synthesis of ergosterol, damaging the fungal cell wall and increasing permeability, leading to leakage of nutrients. Miconazole Nitrate has a wide antifungal spectrum and also exhibits antibacterial activity. It is commonly used to treat fungal infections like athlete’s foot, ringworm, and jock itch, providing relief from itching, redness, and discomfort.

Neomycin (0.5%):

Neomycin belongs to the class of aminoglycoside antibiotics and acts as a broad-spectrum bactericidal agent. It interferes with protein synthesis in susceptible organisms, disrupting ribosomal function and causing misreading of the genetic code. Neomycin is effective against various Gram-positive and Gram-negative bacterial pathogens, making it useful in treating skin infections such as impetigo and infected wounds.

Dose and Method of Administration:

Apply CLOBADIS-NM Cream topically in adults and children over 2 years. Apply twice daily to affected areas. Gently and completely rub the cream into the skin. Importantly, the use of this combination cream should be based on the recommendation and prescription of a healthcare professional. Treatment shouldn’t extend beyond 2 consecutive weeks. Repeated short courses, as prescribed by the physician, can control exacerbations.

Clobetasol Propionate-0.05%, Miconazole Nitrate-2% and Neomycin-0.5% Cream

Warnings and Precautions

When using CLOBADIS-NM Cream externally, it’s crucial to avoid eye contact and refrain from using occlusive dressings. Additionally, prolonged and extensive application should be avoided due to the potential ototoxic and nephrotoxic effects of neomycin sulfate, along with the associated risk of systemic absorption.

Combination Cream Benefits:

Synergistic Action: The combination of Clobetasol Propionate, Miconazole Nitrate, and Neomycin offers a synergistic effect. While Clobetasol Propionate provides anti-inflammatory action, Miconazole Nitrate and Neomycin target fungal and bacterial infections respectively. This three-pronged approach enhances the overall effectiveness of the cream.

Versatile Treatment: The combination cream is suitable for various skin conditions that may involve inflammation, fungal infections, and bacterial complications. It can be used to alleviate symptoms associated with eczema, psoriasis, dermatitis, fungal infections, and superimposed bacterial infections.

Improved Compliance: Combining active ingredients in a single cream provides a convenient, comprehensive treatment approach for patients. Using one cream simplifies the regimen, enhancing patient adherence to prescribed treatment.

Rapid Relief: The potent anti-inflammatory, antifungal, and antibiotic properties of the combination cream offer fast and effective relief from symptoms. Patients may experience reduced itching, redness, swelling, and discomfort, allowing them to experience a significant improvement in their skin condition within a shorter period.

Moreover, combining active ingredients with distinct mechanisms of action reduces the risk of resistance. Specifically in treating skin infections, this feature is crucial due to potential challenges posed by resistance to single agents. Additionally, it enhances the overall efficacy of the treatment.


Use the combination cream of Clobetasol Propionate-0.05%, Miconazole Nitrate-2%, and Neomycin-0.5% for various skin health concerns. Some of the common conditions where this cream can be beneficial include:

Eczema: Chronic inflammatory skin condition, eczema, manifests with redness, itching, and rashes. The anti-inflammatory properties of Clobetasol Propionate help in reducing inflammation, while Miconazole Nitrate targets any accompanying fungal infections, providing relief from symptoms.

Psoriasis: Psoriasis is a chronic autoimmune disease that affects the skin, causing thick, scaly patches. The anti-inflammatory action of Clobetasol Propionate helps in managing the inflammation associated with psoriasis, while the combination cream also addresses any secondary fungal or bacterial infections that may arise.

Dermatitis: Inflammation of the skin, known as dermatitis, can result from various factors like irritants, allergens, or infections. The combination cream helps in reducing inflammation and provides antifungal and antibacterial effects, making it effective in managing different types of dermatitis.

Fungal Infections: The antifungal property of Miconazole Nitrate makes the combination cream useful in treating fungal infections like athlete’s foot, ringworm, and jock itch. It helps in relieving symptoms such as itching, redness, and discomfort associated with these conditions.

Neomycin in the cream effectively treats bacterial infections linked with skin conditions, targeting various bacteria such as Staphylococcus and Streptococcus species.

These bacteria are frequent contributors to skin infections like impetigo and infected wounds. The antibiotic properties of Neomycin aid in combating such bacterial complications.

It is important to note that the use of this combination cream should be based on the recommendation and prescription of a healthcare professional. They can provide guidance on the appropriate usage and duration of treatment based on the specific condition and individual needs.


Clobetasol Propionate, Miconazole Nitrate, and Neomycin cream effectively treats various skin conditions with anti-inflammatory, antifungal, and antibiotic properties. However, it is important to consult a healthcare professional before using any medication or combination cream to ensure appropriate usage and dosage instructions.

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