Cissus quadrangularis: Uses, Benefits, Side Effects and Dosage

People have used Cissus quadrangularis, a traditional medicinal plant, in various traditional medicine systems, especially in Ayurveda.

Various regions and cultures know Cissus quadrangularis by different names. Some of the common names include

Veldt Grape, Devil’s Backbone, Hadjod, Asthisamharaka, Adamant Creeper, Pirandai, Gudari Patha, Harbhanga, Bone Setter, Square-stemmed Cissus, Winged Treebine, Nalleru and Vajravalli

Here are some potential benefits and risks


Bone Health: Traditionally, people have used Cissus quadrangularis for bone health, and some studies suggest that it may aid in treating fractures and osteoporosis. Moreover, people believe it possesses anti-inflammatory and bone-strengthening properties.

Joint Health: Some users claim that Cissus quadrangularis may have positive effects on joint health and may help alleviate joint pain and inflammation. This could be relevant for conditions like arthritis.

Weight Management: There is some evidence suggesting that Cissus quadrangularis may help in weight management by potentially reducing body weight and fat mass. It is thought to have a role in inhibiting the activity of certain enzymes involved in fat storage.

Antioxidant Properties: Cissus quadrangularis contains compounds with potential antioxidant properties; consequently, these compounds may help in combating oxidative stress in the body.

Potential Risks:

Interaction with Medications: Cissus quadrangularis may interact with certain medications. If you are taking any prescription medications or have underlying health conditions, it is essential to consult with a healthcare professional before using supplements.

Gastrointestinal Issues: Cissus quadrangularis supplements may cause stomach upset, like nausea, in some individuals.

Pregnancy and Lactation: Limited information exists on the safety during pregnancy and breastfeeding. Pregnant or lactating individuals should avoid its use unless advised by a healthcare professional.

Allergic Reactions: As with any supplement, there is a potential for allergic reactions. Individuals with known allergies to plants in the Vitaceae family (such as grapes) should exercise caution.

Researchers collectively analyzed the herb, unveiling various compounds. These included flavonoids, triterpenoids, alkaloids, saponins, iridoids, stilbenes, vitamins, steroids, and glycosides. A toxicity assessment indicated an LD50 value exceeding 3000 mg/kg in animals, underscoring its safety. The herb’s aerial parts were studied for analgesic, anti-inflammatory, anticonvulsant, antimicrobial, anticancer, and anti-osteoporotic properties, supporting its colloquial name, Hadjod. Notably, researchers have applied the herb in clinical settings, and individuals in India and the United States have filed several patents, particularly emphasizing the herb’s anti-osteoporotic properties.

A qualified healthcare practitioner should only recommend under their guidance and supervision. Before using Cissus quadrangularis as supplements, seek advice from a healthcare professional. Ensure they’re safe for your health and discuss potential interactions with medications or conditions. Do not use it without proper medical guidance or self-prescribing, as it may pose risks and is not advised.

Cissquad Tablets are available at leading medical stores in India

What Is Cissus Quadrangularis, and What Are Its Health Benefits and Uses?

Cissquad Tablet

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