Cinitapride + Pantoprazole Pharmacokinetics: Benefits, Usage, Indications, Dosage and Side Effects

Cinitapride and Pantoprazole are commonly prescribed together to treat certain gastrointestinal conditions. Cinitapride belongs to the prokinetic drug class, while Pantoprazole is a proton pump inhibitor (PPI). This combination medication, available as Forppi-CP Capsules, is a brand of Bionova and is widely available at leading medical stores in India. It is important to note that this medication should only be taken under the guidance and prescription of a qualified healthcare professional. In this article, we will explore the pharmacokinetics, benefits, usage, indications, dosage, and potential side effects of Cinitapride + Pantoprazole.


Before delving into the specifics of Cinitapride + Pantoprazole, it is essential to understand the pharmacokinetics of each individual component.

Cinitapride is a prokinetic agent that exerts its effects by enhancing the movement and contractions of the gastrointestinal tract. It acts on specific receptors in the gut, known as dopamine D2 receptors, and also has antagonistic effects on serotonin 5-HT4 receptors.

Cinitapride rapidly absorbs after oral administration, reaching peak plasma concentrations within 1-2 hours. The liver extensively metabolizes it, primarily excreting it in the urine.

Cinitapride is a prokinetic medication that acts by facilitating the movement of the intestines. It helps increase the frequency of bowel movements, soften stools, and reduce abdominal pain and discomfort. By enhancing gastrointestinal motility, cinitapride promotes the timely transit of food through the digestive tract, aiding in the relief of constipation and associated symptoms. This prokinetic effect makes cinitapride a valuable option in the management of conditions like chronic constipation, functional bowel disorders, and other gastrointestinal motility disorders. It is important to note that cinitapride should be used under the supervision and guidance of a healthcare professional.

Pantoprazole, on the other hand, is a proton pump inhibitor that reduces the production of gastric acid by selectively inhibiting the H+/K+-ATPase enzyme system in the gastric parietal cells. This inhibition results in a significant decrease in acid secretion. Pantoprazole is well-absorbed after oral administration, and its absorption is not significantly affected by food. It reaches peak plasma concentrations within 2-3 hours. It undergoes hepatic metabolism and is mainly excreted in the urine.

Benefits and Usage:

In GERD, the lower esophageal sphincter (LES) fails to close properly, leading to the reflux of stomach acid into the esophagus. Improving esophageal motility can help enhance the clearance of acid from the esophagus and reduce the frequency and severity of reflux episodes.

Esophageal dysmotility disorders, such as achalasia and esophageal spasm, are characterized by abnormal contractions and movements of the esophagus. These conditions can result in difficulty swallowing (dysphagia), regurgitation, chest pain, and other symptoms. Improving esophageal motility can help alleviate these symptoms and improve the overall functioning of the esophagus.

The combination of Cinitapride and Pantoprazole offers several benefits in the management of various gastrointestinal disorders. Here are some common uses of this combination medication:

Doctors commonly prescribe Cinitapride + Pantoprazole to treat GERD, a condition where stomach acid flows back into the esophagus. The combination works by reducing acid production and improving esophageal motility, thereby relieving symptoms such as heartburn, acid regurgitation and chest pain.

Dyspepsia: Dyspepsia, also known as indigestion, is a common condition that involves persistent or recurrent pain and discomfort in the upper abdomen. Cinitapride + Pantoprazole can help alleviate dyspeptic symptoms by reducing acid secretion and enhancing gastric emptying.

Gastroparesis: Gastroparesis refers to delayed gastric emptying, which can lead to symptoms such as bloating, nausea, and early satiety. The prokinetic action of Cinitapride helps improve gastric motility, while Pantoprazole reduces acid production, collectively providing relief to individuals with gastroparesis.

Functional Dyspepsia: Recurrent or persistent upper abdominal pain characterizes chronic functional dyspepsia without an identifiable organic cause. Manage functional dyspepsia symptoms with Cinitapride + Pantoprazole, reducing acid secretion and improving gastric motility.


Cinitapride + Pantoprazole primarily treat gastrointestinal conditions like GERD, dyspepsia, gastroparesis, and functional dyspepsia. However, it is important to consult a healthcare professional to determine the appropriateness of this medication for your specific condition.

Dosage and How to Take:

The dosage of Forppi-CP Capsules (Pantoprazole-40mg, Cinitapride-3mg) may vary depending on the individual’s age, medical condition, and response to treatment. It is crucial to follow the dosage instructions provided by the prescribing doctor or mentioned on the packaging. Generally, the recommended dosage for adults is one capsule taken orally before meals. It is important to swallow the capsule whole with a glass of water and not to crush or chew it.

It is advisable to take this medication at the same time each day for optimal results. If you miss a dose, it is best to take it as soon as you remember. However, if it is close to the time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for the missed one.

Side Effects:

Like any medication, Cinitapride + Pantoprazole may cause side effects, although not everyone experiences them. Common side effects associated with this combination medication include:

Cinitapride Pantoprazole

Abdominal pain
Dry mouth

These side effects are generally mild and transient. However, if they persist or worsen, it is essential to consult your healthcare provider for further guidance.

In rare cases, Cinitapride + Pantoprazole may cause more serious side effects, such as allergic reactions, severe abdominal pain, black or bloody stools, or signs of liver dysfunction (e.g., jaundice, dark urine). If you experience any of these severe side effects, seek immediate medical attention.

It is worth mentioning that this is not an exhaustive list of side effects and others may occur. It is crucial to discuss potential side effects with your healthcare provider before starting this medication.


Forppi-CP Capsules, a combination of Cinitapride + Pantoprazole, treat gastrointestinal disorders like GERD, dyspepsia, gastroparesis, and functional dyspepsia.

Cinitapride enhances gastrointestinal motility, while Pantoprazole reduces acid secretion, providing relief to individuals with these conditions. However, it is crucial to use this medication only under the guidance and prescription of a qualified healthcare professional. Adhering to the prescribed dosage and understanding potential side effects can help ensure the safe and effective use of Cinitapride + Pantoprazole.