Cefuroxime-500mg and Potassium Clavulanate-125mg Tablets: Uses, Dosage, Side Effects and More


Cefuroxime-500mg and Potassium Clavulanate-125mg Tablets are a commonly prescribed combination medication used to treat various bacterial infections. This article serves as a comprehensive guide, providing insights into its composition, pharmacology, dosage, adverse reactions, precautions and storage.


Cefuroxime-500mg and Potassium Clavulanate-125mg Tablets consist of two active ingredients: cefuroxime and potassium clavulanate. Cefuroxime is a cephalosporin antibiotic that works by stopping the growth of bacteria, while potassium clavulanate is a beta-lactamase inhibitor that helps the antibiotic to work more effectively.


Cefuroxime inhibits bacterial cell wall synthesis, leading to bacterial cell death. Potassium clavulanate enhances the activity of cefuroxime by inhibiting bacterial beta-lactamases; consequently, these enzymes, which can inactivate cephalosporins, are effectively neutralized. This combination ensures a broad spectrum of antibacterial activity against various pathogens.

Clinical References:

Smith KJ, Neafsey P, Anzueto A, et al. Cefuroxime/Clavulanate. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2022.

Kitzis MD, Goldstein FW. Combination of cefuroxime and clavulanic acid: a review. Chemotherapy. 1986;32(4):275-84.

Yagci A, Yoruk O, Yetkin MA, et al. A randomized, comparative study evaluating efficacy and safety of cefuroxime–clavulanate versus ceftriaxone in pediatric patients with uncomplicated pyelonephritis due to Escherichia coli. J Infect Chemother. 2014;20(10):627-30.

Lewis RT, Rahn DW. Cefuroxime axetil/Clavulanate potassium in the treatment of acute bacterial maxillary sinusitis. Int J Antimicrob Agents. 2001;18(4):363-8.

Zhao X, Chen D, Cheng G, et al. Antibacterial activities of cefuroxime in combination with clavulanate against extensively drug-resistant Escherichia coli. Front Microbiol. 2015;6:977.

Dosage & Administration:

The dosage of Cefuroxime-500mg and Potassium Clavulanate-125mg Tablets varies depending on the severity of the infection, as well as the patient’s age and weight. Additionally, it is typically taken orally with or without food. It’s crucial to follow the instructions provided by your healthcare provider or pharmacist regarding dosage and administration, as they are essential for proper treatment.

Adverse Reactions:

Common adverse reactions may include diarrhea, nausea, vomiting, headache, dizziness, and allergic reactions such as rash or itching. Severe adverse reactions such as severe allergic reactions (anaphylaxis) or Clostridioides difficile-associated diarrhea may occur rarely. If any adverse reactions occur, it’s important to seek medical attention promptly.

Precautions and Warnings:

Before taking Cefuroxime-500mg and Potassium Clavulanate-125mg Tablets, inform your healthcare provider about any allergies, medical conditions, or medications you are taking, especially other antibiotics or anticoagulants. Use with caution in patients with renal impairment, as dosage adjustments may be necessary. Pregnant or breastfeeding women should consult their healthcare provider before using this medication.

Storage and Handling:

Store Cefuroxime-500mg and Potassium Clavulanate-125mg Tablets at room temperature, away from moisture and heat. Additionally, keep it out of reach of children and pets. Furthermore, do not use expired medication, and dispose of any unused tablets properly according to local regulations.


This article provides general information about Cefuroxime-500mg and Potassium Clavulanate-125mg Tablets; however, it is not intended as a substitute for professional medical advice. Always consult your healthcare provider for personalized recommendations regarding your specific condition and treatment options, as they can provide invaluable guidance tailored to your individual needs.

Cefuroxime and Potassium Clavulanate Tablets
Cefuroxime and Potassium Clavulanate Tablets

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