Combination of two antibiotics Cefixime and Ofloxacin tablets for surgical prophylaxis.

Cefixime 200 mg and Ofloxacin 200 mg tablets

The choice of antibiotics for surgical prophylaxis is crucial. The selected antibiotics should be effective against the most common bacteria that cause Surgical Site Infections (SSIs). They should be administered at the appropriate time, before the surgical incision to achieve optimal concentrations in the tissues during the procedure. SSIs are a significant concern as they can lead to increased morbidity, mortality, prolonged hospital stays and higher healthcare costs. The combination of Cefixime-200mg and Ofloxacin-200mg (Such as Cefdis-LB-O Tablets) has been used in certain clinical settings & are often utilized for surgical prophylaxis due to their broad-spectrum coverage against both gram-negative and gram-positive bacteria.

Cefixime, a third-generation cephalosporin, targets a wide range of bacteria, inhibiting cell wall synthesis for bacterial cell death. Ofloxacin, an advanced fluoroquinolone, interferes with bacterial DNA replication, preventing growth. The combination offers synergistic effects against diverse bacteria, including aerobic and anaerobic organisms prevalent in surgical infections. This approach broadens coverage, lowering the risk of surgical site infections from resistant bacteria.

Additionally, Cefixime and Ofloxacin have favorable pharmacokinetic properties that make them suitable for surgical prophylaxis. They absorb well orally and reach adequate concentrations in the tissues within a short period. This allows for convenient administration before surgery, ensuring optimal antimicrobial concentrations at the time of incision.

Broader Spectrum of Activity: Third-generation cephalosporins like Cefixime have a broader spectrum of activity compared to earlier generations. They are effective against many gram-negative bacteria and some gram-positive bacteria. Ofloxacin, as an advanced fluoroquinolone, has broad-spectrum activity against both gram-negative and gram-positive bacteria, including some drug-resistant strains.

Resistant Infections:

When the infecting bacteria exhibit resistance to other antibiotics, doctors use the combination of Cefixime and Ofloxacin. These drugs work synergistically, targeting different mechanisms in the bacterial cells, and can be effective against a wider range of resistant pathogens.

Surgical prophylaxis

Several studies have evaluated the effectiveness of the Cefixime-Ofloxacin combination for surgical prophylaxis. One study published in the Journal of Clinical and Diagnostic Research in 2017 evaluated the combination in patients undergoing elective abdominal surgeries. The researchers found that the combination was effective in reducing the incidence of SSIs compared to single-agent prophylaxis. Another study published in the Journal of Infection and Public Health in 2018 assessed the combination in patients undergoing colorectal surgery and reported similar positive outcomes.

While the combination of Cefixime and Ofloxacin can be effective for surgical prophylaxis, it is important to consider potential adverse effects and individual patient factors. Both antibiotics may have side effects, including gastrointestinal disturbances, allergic reactions, and rare cases of serious adverse events. Additionally, patient-specific factors such as allergies, renal function and drug interactions should be considered. During prescribing the combination.

However, the choice of antibiotics and their dosing should be based on specific guidelines, taking into account the type of surgery, patient characteristics, and local resistance patterns. Healthcare professionals should carefully evaluate each case to ensure the optimal antibiotic regimen for surgical prophylaxis.


  • Gupta P, Shukla VK. Comparative Study of Cefixime-Ofloxacin Combination with Single Agents for Prophylaxis in Elective Abdominal Surgeries. J Clin Diagn Res. 2017;11(5):10-12.
  • Halim M, Aryandono T, Isbagio H, et al. Comparison of Cefixime with and without Ofloxacin for Surgical Prophylaxis in Colorectal Surgery. J Infect Public Health. 2018;11(5):650-654.
  • Bratzler DW, Dellinger EP, Olsen KM, et al. Clinical Practice Guidelines for Antimicrobial Prophylaxis in Surgery. Surg Infect (Larchmt). 2013;14(1):73-156.

Here are some other common uses of Cefixime-200mg and Ofloxacin-200mg tablets:

Urinary Tract Infections (UTIs):

Doctors often prescribe Cefixime and Ofloxacin tablets to treat UTIs, including cystitis (bladder infection) and pyelonephritis (kidney infection).

Respiratory and Urinary Tract Infections:

Doctors frequently prescribe this combination for respiratory tract infections like pneumonia and bronchitis, as well as urinary tract infections. The combination covers a wide range of bacteria that commonly cause these types of infections.

Sexually Transmitted Infections (STIs):

Cefixime and Ofloxacin combination may also be used in the treatment of certain sexually transmitted infections, including gonorrhea, when the bacteria causing the infection are susceptible to these antibiotics.

Skin and Soft Tissue Infections:

Cefixime and Ofloxacin tablets can be effective in treating certain skin and soft tissue infections, such as cellulitis and abscesses, caused by susceptible bacteria.

Intra-abdominal Infections:

Intra-abdominal infections refer to infections that occur within the abdominal cavity, including organs such as the liver, gallbladder, appendix, and intestines.

Bacteria entering the abdomen through perforated organs, surgical procedures, or nearby infections can cause these infections. In severe cases, they can lead to life-threatening conditions like peritonitis.

Doctors often use the combination of Cefixime and Ofloxacin to treat intra-abdominal infections because they cover a broad spectrum of common bacteria. The combination helps to target both gram-negative and some gram-positive bacteria, providing effective treatment for a wide range of pathogens involved in intra-abdominal infections.

Typhoid Fever:

The bacterium Salmonella enterica serotype Typhi causes typhoid fever, typically transmitted through contaminated food or water, constituting a systemic infection. High fever, abdominal pain, headache, and gastrointestinal symptoms characterize typhoid fever. Doctors commonly use a combination of Cefixime and Ofloxacin to treat it. These antibiotics help eradicate the Salmonella bacteria from the body and reduce the duration and severity of symptoms. Healthcare providers often prefer combination therapy to target bacteria more effectively and prevent antibiotic resistance development.

Genitourinary Infections:

Genitourinary infections, encompassing both the urinary tract and genital organs, present a diverse spectrum of conditions. First and foremost, urinary tract infections (UTIs) are prevalent, impacting various demographics. Additionally, prostatitis, affecting the prostate gland, is another noteworthy concern. Furthermore, sexually transmitted infections (STIs) contribute to the complexity of genitourinary health. In summary, a comprehensive understanding of genitourinary infections involves recognizing the interconnectedness of UTIs, prostatitis, and STIs.. Cefixime and Ofloxacin can treat genitourinary infections caused by susceptible bacteria. They provide broad-spectrum coverage against both gram-negative and gram-positive bacteria commonly involved in these infections. The combination is effective in eradicating the infecting pathogens, reducing inflammation, and relieving symptoms associated with genitourinary infections.


Septicemia, or bloodstream infection, is a life-threatening condition with bacteria or pathogens in the bloodstream, posing severe health risks. Severe infections, like pneumonia or urinary tract infections, can lead to systemic inflammation affecting any body part, causing sepsis. Cefixime and Ofloxacin combine to treat septicemia when susceptible bacteria cause it. Broad-spectrum antibiotics combat various bacteria, controlling bloodstream infections in septicemia, but selection hinges on specific bacteria, requiring professional assessment.

Cefdis-LB O Tablets are available at most of the leading pharmacies / medical stores in India and can be obtained only with prescription from a registered medical practitioner.

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