Rabeprazole is a rapid acting proton pump inhibitor (PPI). Rabeprazole is a substituted benzimidazole which suppresses gastric acid secretion by inhibiting the gastric H+/ K+ ATPase at the secretory surface of the gastric parietal cell. This enzyme is regarded as the acid (proton) pump within the parietal cell. Rabeprazole blocks the final step of gastric acid secretion. In general word, it blocks the activity of the proton pumps in the stomach wall that produce acid, thereby reducing the amount of acid produced in the stomach.
Domperidone is a peripheral dopamine D2 and D3 receptor antagonist. It provides relief from nausea by blocking receptors at the CTZ .It increases motility in the GIT and increases lower esophageal sphincter . It blocks dopamine receptors in pituitary gland increasing release of prolactin which in turn increases lactation.
Heartburn, GERD,gastric ulcer, duodenal ulcer, erosive gastritis,zollinger Ellison syndrome, post-operative nausea and vomiting.
As prescribed by physician.
ZOLPPI-DSR is contraindicated in patients with known hypersensitivity to rabeprazole, substituted benzimidazole, domperidone or to any component of the formulation. It should not be used whenever stimulation of gastric motility is to be avoided or could be harmful, e.g. in the presence of gastro-intestinal haemorrhage, obstruction or perforation. ZOLPPI-DSR is also contra-indicated in patients with a prolactin-releasing pituitary tumor (prolactinoma) .
Do not take Domperidone, if one is allergic to it or to any other content in the tablets.
Do not take the medicine, if black, tarry stools (bowel motions) or blood in your stools, blockage or tear in the intestines or if there is tumor of the pituitary gland (prolactinoma).
Do not take the drug, if individual has moderate to severe liver disease, heart problems (irregular heart rate or heart failure) or abnormal salt levels in the blood.
Do not crush or chew the tablets, swallow them whole with a glass of water.
Do not take the drug if a person intends to drive or operate heavy machinery as it may cause drowsiness.
Irritability, dry mouth, headache, breast pain or tenderness, abnormal heart rhythm, drowsiness, abnormal milk discharge from breast, diarrhea Increased risk of infections, abdominal pain, constipation, chills or sore throat, belching, flatulence.
Rabeprazole is only recommended for use during pregnancy when benefit outweighs risk. It is recommended that due to the potential for serious adverse reactions in nursing infants, a decision should be made to discontinue nursing or discontinue the drug, taking into account the importance of the drug to the mother.
ZOLPPI-DSR capsules are available in 10X10ís Alu Alu packing
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