Piperacillin 4gm + Tazobactum 0.5gm
TAZODIS is the antibacterial combination of a beta-lactam antibiotic, piperacillin and a beta-lactamase inhibitor, tazobactam. This combination addresses various bacterial infections such as pneumonia, skin infections, appendicitis and peritonitis.
Piperacillin is beta-lactam antibiotic that works by binding to the penicillin-binding proteins (PBPs) and inhibiting the synthesis and assembly of the cell wall. Piperacillin binds to PBP-3, 2B, 2a and 1b that belong to the subgroup of transpeptidase enzymes and blocks the third and last step of peptidoglycan synthesis - the transpeptidation step. This increases the permeability of the cell wall and leakage of the cell contents, which will eventually kill the bacterial cells. Piperacillin is highly stable against the activity of cephalosporinases, penicillinases and beta-lactamases.
Tazobactam is a beta-lactamase inhibitor, whose prime function in this combination is to protect the antibiotic activity of piperacillin. It also broadens the activity spectrum of piperacillin and prevents the latter from being degraded.
This medicine should be administered under medical supervision only.
TAZODIS injection is contraindicated in patients with hypersensitivity towards piperacillin and tazobactam. It is also contraindicated in patients with coagulation disorders, hepatic impairment, renal impairment, low levels of potassium in the blood and Clostridium difficile infection.
Adverse effects of this medication include nausea, vomiting, abdominal pain, constipation, skin rash, pain and swelling in the area where the medication is injected.
There are no sufficient and well-controlled studies when it comes to piperacillin and tazobactam administration in pregnant women and nursing mothers. Therefore, if you are pregnant or nursing, discuss with your doctor about your condition before taking this medicine.
TAZODIS injection is available in vial with WFI with outer carton pack.
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Keep the medicines out of the children’s reach. This product is to be stored as recommended. Do not exceed the recommended dosage. Do not use this information in place of a visit, consultation or advice of your healthcare providers.