Levocetirizine is a third generation sedative antihistamine. It prevents the release of other allergy chemical an dincrease blood supply to the area, provides relief from the typical symptoms of hay fever.
Ambroxol is a secretolytic agent used in the treatment of respiratory diseases associated with viscid or excessive mucus .Ambroxol is an active N-desmethyl metabolite of the mucolytic, bromhexine. Ambroxol is shown to exert several activities, as follows: Its mucolytic activity by which it facilitates breakdown of acid mucopolysaccharide fibres in the mucous making it thinner and less viscous and, therefore, easy for expectoration; it stimulates the ciliary activity thereby improving mucokinesis (transport of mucous); it stimulates production of pulmonary surfactant, a substance found to play a major role in the lung host defense mechanism, thereby further protecting against lung inflammation and infection; also exhibits anti-inflammatory and antioxidant activity. When administered orally, onset of action occurs after about 30 minutes.
Acute and chronic diseases of respiratory tract, with symptoms of thick mucus retention,bronchitis, bronchial asthma, bronchiecstasia and silicosis.
As directed by the Physician .
Contraindicated in patients with a history of hypersensitivity to any of the component of the product or its parent compounds. It is also contraindicated in patients with completely impaired renal function and with gastric ulceration.
Caution needed for pregnant and breastfeeding women.
Montelukast and levocetirizine are generally well tolerated.The most commonly reported adverse events are headache,asthma and upper respiratory tract infections.
Ambroxol hydrochloride has not been shown to have any teratogenic or toxic effects on the foetus. It is advisable to avoid use during the first trimester of pregnancy. Since levocetirizine is excreted in breast-milk the combination is not recommended during lactation.
PRIMOCET-AX tablets are available in a 10X10ís blister packing
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