Ambroxol is a clinically proven systemically active mucolytic agent. When administered orally onset of action occurs after about 30 minutes. The breakdown of acid mucopolysaccharide fibers makes the sputum thinner and less viscous and therefore more easily removed by coughing. Although sputum volume eventually decreases, its viscosity remains low for as long as treatment is maintained. Ambroxol increases content of surfactant in lungs, which is dealt with strengthening of synthesis of the last and secretion in alveolar pneumocytes, and also with breach of its disintegration. The medicinal product increases mucociliar transport of phlegm. It suppresses coughing insignificantly.
Guaiphenesin has an expectorant action. It reduces sputum viscosity by increasing the volume and water content of the bronchial secretion thereby facilitating the expectoration of sputum.
Terbutaline is a selective beta2 -adrenergic agonist which predominantly stimulates beta2-receptors, thus producing relaxation of bronchial smooth muscle .Ambroxol possesses mucokinetic (improvement in mucus transport) and secretolytic (liquefies secretions) properties. It promotes the removal of tenacious secretions in the respiratory tract and reduces mucus stasis (arresting the secretion of mucus).
Menthol has a cooling effect on the throat.It has been suggested that benefits of menthol may be due to an effect on calcium channels of sensory nerves.
PENTAKOF-TM Syrup is indicated for the treatment of productive cough when associated with bronchospasm in conditions such as bronchitis,bronchial asthma,COPD,bronchiectasis and emphysema.
As directed by physician.
The medication is contraindicated in patients with hypersensitivity to any ingredient of the formulation.
While treating cough as a symptom,it is important to make every effort to determine and treat appropriately the underlying cause ,such as specific infection.
Caution should be exercised while prescribing PENTAKOF-TM Syrup to the adults and children with hypertension,cardiovascular disease,uncontrolled DM,hyperthyroidism,seizures or in patients who are unusually hypersensitive to sympathomimetic amines.
Since amroxol may disrupt the gastric mucosal barrier ,the syrup should be used with care in patients with a history of peptic ulceration.
Less common side effects are nervousness and tremor. Most common are increased heart rate, palpitation, dizziness, headache, vomiting, nausea, drowsiness, sweating and muscle cramps.
For the safety in pregnancy and lactation, probable benefits should be weighed against possible risk, before prescribing.
PENTAKOF-TM Syrup is available as 100 ml bottle pack.
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