PENTAKOF-TM Syrup

Each 5 ml contains

  • Ambroxol HCl 15 mg
  • Guaiphenisin 50 mg
  • Terbutalin 1.5 mg
  • Menthol 2.5 mg

DESCRIPTION

Ambroxol is a clinically proven systemically active mucolytic agent. When administered orally onset of action occurs after about 30 minutes. The breakdown of acid mucopolysaccharide fibers makes the sputum thinner and less viscous and therefore more easily removed by coughing. Although sputum volume eventually decreases, its viscosity remains low for as long as treatment is maintained. Ambroxol increases content of surfactant in lungs, which is dealt with strengthening of synthesis of the last and secretion in alveolar pneumocytes, and also with breach of its disintegration. The medicinal product increases mucociliar transport of phlegm. It suppresses coughing insignificantly.

Guaiphenesin has an expectorant action. It reduces sputum viscosity by increasing the volume and water content of the bronchial secretion thereby facilitating the expectoration of sputum.

Terbutaline is a selective beta2 -adrenergic agonist which predominantly stimulates beta2-receptors, thus producing relaxation of bronchial smooth muscle .Ambroxol possesses mucokinetic (improvement in mucus transport) and secretolytic (liquefies secretions) properties. It promotes the removal of tenacious secretions in the respiratory tract and reduces mucus stasis (arresting the secretion of mucus).

Menthol has a cooling effect on the throat.It has been suggested that benefits of menthol may be due to an effect on calcium channels of sensory nerves.

INDICATIONS

PENTAKOF-TM Syrup is indicated for the treatment of productive cough when associated with bronchospasm in conditions such as bronchitis,bronchial asthma,COPD,bronchiectasis and emphysema.

DOSAGE & ADMINISTRATION

As directed by physician.

CONTRAINDICATIONS

The medication is contraindicated in patients with hypersensitivity to any ingredient of the formulation.

PRECAUTIONS

While treating cough as a symptom,it is important to make every effort to determine and treat appropriately the underlying cause ,such as specific infection.

Caution should be exercised while prescribing PENTAKOF-TM Syrup to the adults and children with hypertension,cardiovascular disease,uncontrolled DM,hyperthyroidism,seizures or in patients who are unusually hypersensitive to sympathomimetic amines.

Since amroxol may disrupt the gastric mucosal barrier ,the syrup should be used with care in patients with a history of peptic ulceration.

ADVERSE EFFECTS

Less common side effects are nervousness and tremor. Most common are increased heart rate, palpitation, dizziness, headache, vomiting, nausea, drowsiness, sweating and muscle cramps.

PREGNANCY & LACTATON

For the safety in pregnancy and lactation, probable benefits should be weighed against possible risk, before prescribing.

PRESENTATION

PENTAKOF-TM Syrup is available as 100 ml bottle pack.

CAUTION

The medical information on this site is provided as an information resource only, and is not to be used or relied on for any diagnostic or treatment purposes. This information is not intended to be patient education, does not create any patient-physician relationship, and should not be used as a substitute for professional diagnosis and treatment. Please note it is dangerous to take any medication without doctor’s prescription or professional advice from a registered health practitioner. Always follow the instructions of physician / doctor / registered medical practitioner before using any medicine. Do not exceed the recommended dosage. Keep all medicines away from your children. Store as recommended. Please consult your health care provider, before making any healthcare decisions or for guidance about a specific medical condition. The allopathic medicine as per the law in India must be sold by retail pharmacies holding valid trading drug license only.

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