Bromhexine 8 mg

Each 5 ml contains

  • Bromhexine hydrochloride IP 8 mg
  • Phenylephrine hydrochloride IP 5 mg
  • Guaiphenesin IP 100 mg
  • Chlorpheniramine maleate IP 2 mg
  • Paracetamol IP 325 mg


Bromhexine is intended to support the body’s mechanism for clearing mucus from the respiratory tract. It is a secreolytic, increasing the production of mucus in the respiratory tract and makes the phlegm thinner and less viscous.

Phenylephrine is a sympathomimetic vasoconstrictor that has been used as a nasal decongestant for many years. Phenylephrine constricts the blood vessels in the nasal mucous membranes and allows the air passages to open up. It is a relatively selective alpha-adrenoceptor agonist. The majority of the sympathomimetic action is due to direct stimulation of the adrenoceptors. At 2 therapeutic doses, it does not cause significant stimulation of the central nervous system.

Guaiphenesin has an expectorant action. It reduces sputum viscosity by increasing the volume and water content of the bronchial secretion thereby facilitating the expectoration of sputum.

Chlorpheniramine maleate is a first generation antihistamine which provides prompt relief of itchy-watery eyes, runny nose, sneezing, itching of the nose or throat due to respiratory allergies. The effectiveness of first-generation antihistamines in blocking sneezing in colds may be due primarily to neuropharmacological manipulation of histaminic and muscarinic receptors in the medulla.

Paracetamol (acetaminophen) is a pain reliever and a fever reducer. The exact mechanism of action of is not known. Paracetamol is used to treat many conditions such as headache, muscle aches, arthritis, backache, toothaches, colds, and fevers. It relieves pain in mild arthritis but has no effect on the underlying inflammation and swelling of the joint.


PENTADRYL-P Tablet is indicated in the treatment of upper respiratory tract infections associated with cough, cold, fever and bodyache.


As directed by physician.


The use of PENTADRYL-P Tablet is contraindicated in patients with:

  • Hypersensitivity to any of the ingredients of the formulation.
  • Severe hypertension.


In case a hypersensitivity reaction occurs which is rare, PENTADRYL-P Tablet should be discontinued.

  • PENTADRYL-P Tablet contains Paracetamol and therefore should not be used in conjunction with other Paracetamol containing products.
  • PENTADRYL-P Tablet should be used with caution in patients with renal or hepatic dysfunction, diabetes mellitus, hyperthyroidism, cardiovascular problems, epilepsy and closed angle glaucoma.
  • It is advisable not to drive or operate machinery when on treatment with PENTADRYL-P Tablet.
  • Concurrent administration of CNS depressants may have additive effect leading to sedation/somnolence.


PENTADRYL-P tablet is generally well tolerated and adverse events are rare. Hypersensitive individuals may display ephedrine-like reactions such as tachycardia, palpitations, headache, dizziness and nausea. Use of sympathomimetics has been associated with fear, anxiety, restlessness, tremor, weakness, dysuria, insomnia, hallucinations and convulsions. Chlorpheniramine may cause sedation. Guaiphenesin may cause gastrointestinal discomfort, nausea and vomiting.


There are adequate and well controlled data in pregnant women.PENTADRYL-P tablet should be used during pregnancy only if the potential benefits justifies the potential risks to the fetus.


There are adequate and well controlled data in pregnant women.PENTADRYL-P tablet should be used during pregnancy only if the potential benefits justifies the potential risks to the fetus.


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