Each NOLL OZ tablet contains ofloxacin 200mg & ornidazole 500mg.
NOLL OZ is the anti-bacterial and anti-protozoal combination of ofloxacin and ornidazole. This combination is highly effective against amoebiasis, amoebic dysentery, sexually transmitted diseases and respiratory tract infections.
Ofloxacin works by blocking the cell division in the bacterial cells. This drug belongs to the class of fluoroquinolones. Ofloxacin acts on the enzymes, DNA gyrase and topoisomerase IV, which are associated with DNA unwinding and DNA supercoiling processes during the DNA replication. Ofloxacin hampers the functions of these enzymes and arrests the cell division process in the bacterial cells, which will eventually lead to their death.
Ornidazole is a broad spectrum antibacterial and antiprotozoal agent; it is a nitroimidazole derivative. Once it enters the bacterial cells by diffusion, the redox proteins present there will reduce the nitro group of the drug and form intermediate metabolites. These intracellular intermediate metabolites damage the bacterial DNA and other biomolecules present in the bacterial cells and cause their death. Ornidazole is also observed to cause DNA helix destabilization and strand breakage, which will also lead to the death of the bacterial cells and prevent their future growth.
As directed by the physician
NOLL OZ tablet is contraindicated in patients with hypersensitivity towards ofloxacin and ornidazole. This medicine is also contraindicated in patients with dehydration, Clostridium difficile infection, peripheral neuropathy, rapid heartbeat, tendon rupture, low potassium levels in the blood and myasthenia gravis.
Adverse effects of this medicine include loss of appetite, headache, abdominal and stomach pain, diarrhea, numbness in hands and feet, nausea, vomiting, constipation, accumulation of gas, dizziness and unusual tiredness.
There are no sufficient and well-controlled studies when it comes to ofloxacin and ornidazole administration in pregnant women and nursing mothers. Therefore, if you are pregnant or nursing, discuss with your doctor about your condition before taking this medicine.
NOLL OZ tablets are available in 10X10’s Alu Alu packing.
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Keep the medicines out of the children’s reach. This product is to be stored as recommended. Do not exceed the recommended dosage. Do not use this information in place of a visit, consultation or advice of your healthcare providers.