Each tablet of NEVIMOX-SB 500 contains amoxicillin 250mg and sulbactam 250mg
NEVIMOX SB- 500 is an antibiotic combination of the antibiotic amoxicillin and the beta-lactamase inhibitor, sulbactam. This oral medication is effective against the broad spectrum of micro-organisms. This product works by inhibiting the cell wall synthesis and thereby preventing the growth of the bacterial cells. The major bacterial infections that can be addressed using NEVIMOX-SB 500 are gonorrhea, pneumonia, genitourinary tract infections, etc.
Amoxicillin is a beta-lactam antibiotic that belongs to the class of aminopenicillins and it is derived from ampicillin. Amoxicillin binds to the penicillin-binding-protein 1A which is located in the cell envelope of the bacterial cells. The penicillin-sensitive transpeptidase-C terminal domain of the PBPs is acylated by the amoxicillin and the domain becomes inactivated. This leads to the inhibition of cross-linkage between the linear peptidoglycan polymer chains, which in turn, cause the bacterial cell death. Amoxicillin is said to be highly susceptible to beta-lactamase activity and thus it has to be administered in combination with a beta-lactamase inhibitor such as sulbactam.
Sulbactam is a beta-lactamase inhibitor and its prime function is to protect amoxicillin’s antibiotic activity. Sulbactam also possesses a beta-lactam ring which binds to the beta-lactamase enzyme present within the bacterial cell wall. This binding prevents the binding of the enzyme to the beta-lactam ring of amoxicillin and eventually protects the latter from enzymatic degradation.
As directed by the physician
NEVIMOX-SB 500 tablets are contraindicated in patients with hypersensitivity towards its ingredients and penicillins. It is also contraindicated in patients with hepatic impairment, renal impairment and Clostridium difficile bacterial infection.
Adverse effects of this medication are nausea, vomiting, diarrhea, chest pain, painful urination, impaired liver functions, loss of appetite, abdominal pain, sore throat and body aches.
There are no sufficient and well-controlled studies when it comes to amoxicillin administration in pregnant women and nursing mothers. Therefore, if you are pregnant or nursing, discuss with your doctor about your condition before taking this medicine.
NEVIMOX-SB 500 tablets are available in 10X10's Alu Alu packing.
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Keep the medicines out of the children’s reach. This product is to be stored as recommended. Do not exceed the recommended dosage. Do not use this information in place of a visit, consultation or advice of your healthcare providers.