Amoxicillin 1000mg and Sulbactam 500mg
NEVIMOX SB is an antibacterial combination of semi-synthetic antibiotic amoxicillin and the beta-lactamase inhibitor, sulbactam. This combination is synergistic and effective against both gram+ve and gram-ve bacteria. It works by inhibiting the cell wall synthesis and eventually preventing the growth of the bacterial cells.
Amoxicillin is a beta-lactam antibiotic that belongs to the class of aminopenicillins and it is derived from ampicillin. Amoxicillin binds to the penicillin-binding-protein 1A which is located in the cell envelope of the bacterial cells. The penicillin-sensitive transpeptidase-C terminal domain of the PBPs is acylated by the amoxicillin and the domain becomes inactivated. This blocks the cross-linkage between the linear peptidoglycan polymer chains, which in turn, leads to increased cellular permeability. This will eventually cause the death of the bacterial cells.
Amoxicillin is more active on Gram+ve bacteria than on Gram-ve bacteria, as the former have higher peptidoglycan content in their cell wall. Amoxicillin is an effective antibiotic with excellent tissue penetration, minimal plasma protein binding, and an anaerobic activity. However, it is highly susceptible to beta-lactamase activity.
Sulbactam is a beta-lactamase inhibitor and its prime function is to protect amoxicillin’s antibiotic activity. Sulbactam enhances the efficiency of the drug by irreversibly inhibiting the activity of both plasma-mediated and chromosomal beta-lactamase in the bacterial cell wall.
This medicine has to be administered under medical supervision only.
NEVIMOX SB injection is contraindicated in patients with hypersensitivity towards its ingredients and penicillins. It is also contraindicated in patients with hepatic impairment, renal impairment and Clostridium difficile bacterial infection.
Adverse effects of this medication are nausea, vomiting, diarrhea, chest pain, painful urination, impaired liver functions, loss of appetite, abdominal pain, sore throat and body aches.
There are no sufficient and well-controlled studies when it comes to amoxicillin administration in pregnant women and nursing mothers. Therefore, if you are pregnant or nursing, discuss with your doctor about your condition before taking this medicine.
NEVIMOX SB is available in 20mL & 10mL WFI pack
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