Magaldrate/simethicone suspension is an antacid and antiflatulent combination. The antacid works by neutralizing stomach acid and increasing the pH of the stomach. The antiflatulent works by breaking up gas bubbles, which makes gas easier to eliminate.Magaldrate is a hydroxymagnesium aluminate complex that is converted rapidly in gastric acid to Mg(OH)2 and Al(OH)3, which are absorbed poorly and thus provide a sustained antacid effect.
Simethicone is an anti-foaming agent that decreases the surface tension of gas bubbles, causing them to combine into larger bubbles in the stomach that can be passed more easily. Simethicone does not reduce or prevent the formation of gas in the digestive tract, rather, it increases the rate at which it exits the body. However, simethicone can relieve pain caused by gas in the intestines by decreasing foaming, which then allows for easier passing of flatulence.
NEVIGEL Suspension is indicated to relieve symptoms of dyspepsia, heartburn, acid indigestion, sour stomach, gastroesophageal reflux and hiatal hernia. It is also prescribed in hyperacidity associated with peptic ulcers, gastritis and esophagitis. Magaldrate may be given to children if necessary. Also indicated for the relief of flatulence, abdominal distension and windy colic.
2-4 teaspoonfuls after 20-60 minutes of meal and before sleep or on the basis of physician’s prescription.
Magaldrate is contraindicated in patients with known hypersensitivity to magnesium and aluminium. It is also contraindicated in patients with impaired renal functions.
Caution should be exercised in decreased kidney function, hypophosphataemia and weak people.
GI side-effects are uncommon. Occasionally, if excessive amount is consumed, diarrhea, constipation or regurgitation may occur.
The safety of Magaldrate+Simethicone is unknown and may or may not be harmful to an unborn fetus. Magaldrate+Simethicone may pass through breast milk. Nursing mothers should consult a healthcare provider before taking Magaldrate+Simethicone suspension.
NEVIGEL Suspension is available as a suspension. Every 5 ml contains Magaldrate 400 mg and Simethicone 20 mg. The total content in each bottle is 170 ml.
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