Each 5mL of NEOMENTIN CV dry syrup consists of Amoxicillin trihydrate (equivalent to amoxicillin) 400mg and diluted potassium clavulanate IP (equivalent to clavulanic acid) 57mg.
NEOMENTIN CV is a potent antibiotic combination of amoxicillin and clavulanic acid. Amoxicillin is a beta-lactam antibiotic with broad-spectrum activity, while clavulanic acid is a beta-lactamase inhibitor whose prime function is to prevent the enzymatic degradation of amoxicillin by beta-lactamases present in the bacterial cell wall.
Like other beta-lactam antibiotics, amoxicillin works by inhibiting the cell wall synthesis in bacteria. Amoxicillin interferes with the transpeptidation step, which is the last step of peptidoglycan synthesis and prevents the cross-linking reaction. This cross-linking is crucial for the maintenance of cellular integrity in bacteria. Lack of cross-linkage in the cell wall increases the permeability and eventually leads to the death of the bacterial cells.
Clavulanic acidís role in this combination is to protect the antibiotic activity of amoxicillin. Amoxicillin is highly susceptible to beta-lactamases and cephalosporinases activity; thus, it has to be administered in combination with clavulanic acid, which will bind to the beta-lactamases and let amoxicillin perform its activity.
As directed by the physician
NEOMENTIN CV is contraindicated in patients with hypersensitivity towards amoxicillin and clavulanic acid and other beta-lactam antibiotics. It is also contraindicated in patients with renal impairment, liver disorders, Clostridium difficile infection, asthma, seizure disorders and jaundice.
Adverse effects of this medicine include diarrhea, nausea, vomiting, abdominal pain, dark urine, sore throat and unusual tiredness.
There are no sufficient and well-controlled studies when it comes to amoxicillin and clavulanic acid administration in pregnant women and nursing mothers. Therefore, if you are pregnant or nursing, discuss with your doctor about your condition before taking this medicine.
NEOMENTIN-CV DS is available in 30mL bottle with carton.
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Keep the medicines out of the childrenís reach. This product is to be stored as recommended. Do not exceed the recommended dosage. Do not use this information in place of a visit, consultation or advice of your healthcare providers.