Pepsin is an enzyme whose zymogen (pepsinogen) is released by the chief cells in the stomach and that degrades food proteins into peptides.
Simethicone is used to relieve painful pressure, hiccups, bloating and fullness caused by excess gas in the stomach and intestines in adults as well as in children.
Simethicone belongs to class of medications called surface active substances. It is an antifoaming agents and works by acting on inner lining of intestine and allowing gas bubbles to come together more easily helping to release trapped wind.
Other ingredients of the medicine may cause allergic effects
These drugs are used to promote digestion of food as a replacement therapy in condition of their deficiency specially in atrophic gastritis, gastric carcinoma, pernicious anaemia or pancreatic insufficiency etc. amylolytic (diastase) enzymes are used in combination as appetite stimulants and health tonics.