Glutathione & Vitamin C are known to promote brighter skin complexion and evens skin tone, Helps delay signs of ageing
Studies show that Glutathione acts as a Tyrosinase Inhibitor. Tyrosinase is an enzyme that catalyzes the biosynthesis of melanin which is the culprit for skin darkening.
Skin pigmentary abnormalities are seen as aesthetically unfavorable and have led to the development of cosmetic and therapeutic treatment modalities of varying efficacy. Hence, several putative depigmenting agents aimed at modulating skin pigmentation are currently being researched.
The oral use of Reduced Glutathione(L-glutathione) inhibits the Tyrosinase Activity. Once it has been inhibited, the metabolic pathway then reverses its course going to the synthesis of light pigmented melanin called Phaeomelanin instead of synthesizing dark pigmented melanin called Eumelanin. The cycle continuously flow as long as the presence of L-glutathione co-exists in the metabolic pathway of melanin. Finally, light skin will reveal to the surface gradually changing your complexion.
The tyrosinase activity is inhibited by number of compounds including L-Glutathione and Vitamin C. In the skin, the enzyme glutathione reductase (GR) is responsible for producing Reduced Glutathione. Lower levels of Reduced Glutathione leads to greater melanin synthesis. Glutathione, when taken orally has a skin lightening effect. But, it affects the new melanogenesis and really not the existing pigment.
Melanocytes, the pigment producing cells of the follicular and interfollicular epidermis, produce a specialized lysosomal related organelle termed the melanosome. Within the melanosome, biopolymers of the pigment melanin are synthesized to give hair and skin, as well as other tissue, its colour. This melanin synthesis involves a bipartite process in which structural proteins are exported from the endoplasmic reticulum and fuse with melanosome-specific regulatory glycoproteins released in coated vesicles from the Golgi-apparatus. Melanin synthesis ensues subsequent to the sorting and trafficking of these proteins to the melanosome. Hyperpigmentary disorders of the skin such as melasma, age spots or solar lentigo can result from the overproduction and accumulation of melanin. As such, depigmenting agents can have potent effects by acting on one or more steps in the melanogenic pathway, melanosome transfer or post-transfer pigment processing and degradation.
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