Forppi DSR

Each tablet contains

  • Pantoprazole 40 mg
  • Domperidone 30mg DSR

DESCRIPTION

FORPPI-DSR is a combination of Pantoprazole 40mg and Domperidone 30mg.Pantoprazole is a proton pump inhibitor that decreases the amount of acid produced in the stomach. It suppresses the final step in gastric acid production by covalently binding to the enzyme system at the secretory surface of the gastric parietal cell. This effect leads to inhibition of both basal and stimulated gastric acid secretion, irrespective of the stimulus. The binding to the enzyme system results in duration of antisecretory effect that persists longer than 24 hours. . Pantoprazole, being a weak base, is highly ionized at low pH and readily accumulated in the highly acidic canalicular lumen of the stimulated parietal cell in the stomach. In this acidic environment, it is protonated and rapidly converted to a cationic cyclic sulphonamide. The sulphonamide binds covalently to cysteine residues on the luminal (acidic) surface of H+ / K+-ATPase to form a mixed disulphide; thus causing irreversible inhibition of the gastric proton pump. This inhibition of the gastric proton pump or H+ / K+-ATPase (which represents the final step in the secretory process), suppresses gastric acid secretion.

Domperidone is a peripheral dopamine antagonist, which regulates the motility of gastric and small intestinal smooth muscle. Antiemetic activity is due to the blockade of dopamine receptors in the chemoreceptor trigger zone.Domperidone, a benzimidazole derivative (structurally related to the butyrophenones), acts by selectively antagonizing the peripheral dopaminergic D2 receptors in the gastrointestinal (G.I.) wall, thereby enhancing gastrointestinal peristalsis and motility and increasing Lower Esophageal Sphincter (LES) tone.

INDICATIONS

For relief in burping-up stomach juices and gas (regurgitation or reflux) caused by gastroesophageal reflux disease (GERD) or a hiatal hernia.

To control pain in gallbladder pain (biliary colic) or in inflammation (cholecystitis).

DOSAGE & ADMINISTRATION

As directed by the physician

CONTRAINDICATIONS

Pantoprazole is contraindicated in heptic impairment, hypersensitivity. Domperidone is contraindicated in the history of hypersensitivity to dimenhydrinate or related compounds.

PRECAUTION

Caution should be excercised when domperidone is administered with other orally administered drugs,particularly those with SR or enteric coated formulations.

ADVERSE EFFECTS

Nausea, drowsiness, flatulence and dry mouth.

PREGNANCY & LACTATON

FORPPI-DSR is contraindicated in pregnancy.It should be used with caution in lactating mothers.

PRESENTATION

FORPPI-DSR tablets are available in a 10X10ís Alu Alu packing

CAUTION

The medical information on this site is provided as an information resource only, and is not to be used or relied on for any diagnostic or treatment purposes. This information is not intended to be patient education, does not create any patient-physician relationship, and should not be used as a substitute for professional diagnosis and treatment. Please note it is dangerous to take any medication without doctorís prescription or professional advice from a registered health practitioner. Always follow the instructions of physician / doctor / registered medical practitioner before using any medicine. Do not exceed the recommended dosage. Keep all medicines away from your children. Store as recommended. Please consult your health care provider, before making any healthcare decisions or for guidance about a specific medical condition. The allopathic medicine as per the law in India must be sold by retail pharmacies holding valid trading drug license only.

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