FORPPI-D is a combination of pantoprazole and domperidone.Pantoprazole is a proton pump inhibitor that decreases the amount of acid produced in the stomach. It suppresses the final step in gastric acid production by covalently binding to the enzyme system at the secretory surface of the gastric parietal cell. This effect leads to inhibition of both basal and stimulated gastric acid secretion, irrespective of the stimulus. The binding to the enzyme system results in duration of antisecretory effect that persists longer than 24 hours.
Domperidone is a peripheral dopamine antagonist, which regulates the motility of gastric and small intestinal smooth muscle. Antiemetic activity is due to the blockade of dopamine receptors in the chemoreceptor trigger zone.
This combination medication contains proton pump inhibitor and an antidopaminergic agent, prescribed for dyspepsia and gastro-esophageal reflux disease (GERD).
Once or Twice capsule once daily or as directed by the physician.
Pantoprazole is contraindicated in heptic impairment, hypersensitivity. Domperidone is contraindicated in the history of hypersensitivity to dimenhydrinate or related compounds.
FORPPI-D is not recommended in child 12 yrs. Long-term therapy may lead to bacterial overgrowth in the GIT.
Domperidone: Increases serum prolactin levels resulting to galactorrhoea in females and gynaecomastia in males. Hypertensive crisis in patients with phaeochromocytoma.
Nausea, drowsiness, flatulence and dry mouth.
Piroxicam may harm an unborn baby, especially shouldn’t take piroxicam during your last three months of pregnancy. The medicine is found in breast milk and could hurt a nursing baby. Don’t take Piroxicam while breastfeeding a baby.
FORPPI-D tablets are available in a 10X10’s Alu Alu packing
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