Doxporin CV

Composition:

Each film-coated DOXPORIN CV tablet contains anhydrous cefpodoxime 200mg and diluted potassium clavulanate (eq to clavulanic acid) 125mg.

Description:

DOXPORIN-CV is the brand name for the antibiotic combination of clavulanic acid and cefpodoxime. Cefpodoxime is a beta-lactam antibiotic that belongs to the class of third-generation cephalosporins. Clavulanic acid is a beta-lactamase inhibitor whose prime function is to protect the antibiotic activity of cefpodoxime.

Cefpodoxime works by inhibiting the cell wall synthesis in bacteria. This drug binds to the Penicillin Binding Protein 3 and blocks the transpeptidation step of peptidoglycan synthesis in bacteria. The transpeptidation step is crucial for the cross-linking in the bacterial cell wall, and without this cross-linkage, the bacterial cells cannot hold their content within them. This leakage will eventually lead to the death of the bacterial cells. Cefpodoxime is stable against the activity of penicillinases, cephalosporinases and different beta-lactamases.

Clavulanic acid, which also possesses a beta-lactam ring binds to the beta-lactamase enzyme of the bacteria, when administered along with cefpodoxime and thereby prevents the binding of the beta-lactamase enzyme to cefpodoxime. Cefpodoxime is susceptible to degradation by a few beta-lactamases and clavulanic acid prevents this interaction. Cefpodoxime in combination with clavulanic acid is effective against several Gram +ve and Gram-ve bacteria.

Indications:

  • Bacterial exacerbations of chronic bronchitis
  • Community-acquired pneumonia
  • Gonorrhea and associated infections
  • Maxillary sinusitis
  • Pharyngitis/ Tonsillitis
  • Skin / Skin structure infections
  • Urinary tract infections
  • Respiratory tract infections
  • Acute Otitis Media

Dosage and Administration:

As directed by the physician

Contraindication:

DOXPORIN CV tablet is contraindicated in patients with hypersensitivity towards cefpodoxime and clavulanic acid, Clostridium difficile infection, hepatic impairment, renal impairment and seizure disorders

Adverse Effects:

Adverse effects of this medicine include GI disturbances, nausea, vomiting, diarrhea, rashes and itching.

Precaution:

There are no sufficient and well-controlled studies when it comes to cefpodoxime and clavulanic acid administration in pregnant women and nursing mothers. Therefore, if you are pregnant or nursing, discuss with your doctor about your condition before taking this medicine.

Presentation:

DOXPORIN CV tablets are available in 10X1X6's Alu Alu packing.

Disclaimer:

The medical information on this website is provided as an information resource only. The information on this website is not intended to be a substitute for professional medical advice, diagnosis or treatment. Always seek the advice of your physician or other qualified health provider or a medical practitioner with any questions you may have regarding a medical condition, or to assist in understanding any information or in applying information, that you might have come across, on this website. Please note that it dangerous to take any medication without doctor’s prescription or professional advice from a registered health practitioner. Make sure to follow the instructions of physician/doctor/ registered medical practitioner before using this medicine. Medical and health information changes constantly. Therefore, the information provided on this website should not be considered current, complete or exhaustive. Please consult your healthcare provider, before coming to any conclusions with respect to your health condition or for guidance about a specific medical condition. The allopathic medicine as per the law in India must be sold by retail pharmacies holding valid trading drug license only.

Keep the medicines out of the children’s reach. This product is to be stored as recommended. Do not exceed the recommended dosage. Do not use this information in place of a visit, consultation or advice of your healthcare providers.

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