DOMZEL-O Capsule is a combination of proton pump inhibitor and antidopaminergic agent. Domperidone is a peripheral dopamine antagonist, which regulates the motility of gastric and small intestinal smooth muscle. Antiemetic activity is due to the blockade of dopamine receptors in the chemoreceptor trigger zone.
Omeprazole belongs to a class of antisecretory compounds, the substituted benzimidazoles, that suppress gastric acid secretion by specific inhibition of the enzyme system at the secretory surface of the gastricparietal cell. Because this enzyme system is regarded as the acid (proton) pump within the gastric mucosa, omeprazole has been characterized as a gastric acid-pump inhibitor, in that it blocks the final step of acid production.
GERD,heart burn & hyperacidity,reflux oesophagitis,regurgitation & flatulence,gastric & peptic ulcer.
The usual recommended dose of Pantoprazole + Domperidone is one capsule daily before breakfast. Swallow capsule as a whole, do not chew the capsule.
Domperidone is contraindicated in conditions associated with rise in prolactin level. Omeprazole is contraindicated in hypersensitive patients.
Generally well tolerated. Most common side effects are somnolence,dizziness,dry mouth and blurring of vision.
There was no evident harm on the development of the fetus.Pantoprazole has been found to pass through the breast milk. Risks and benefits are recommended for consideration in determining the use of therapy for the mother and child.
DOMZEL-O capsules are available in 10X15ís strip pack.
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