DOMZEL-O Capsule

Domperidone 10 mg Capsule

Each capsule contains

  • Domperidone 10 mg
  • Omeprazole 20 mg

DESCRIPTION

DOMZEL-O Capsule is a combination of proton pump inhibitor and antidopaminergic agent. Domperidone is a peripheral dopamine antagonist, which regulates the motility of gastric and small intestinal smooth muscle. Antiemetic activity is due to the blockade of dopamine receptors in the chemoreceptor trigger zone.

Omeprazole belongs to a class of antisecretory compounds, the substituted benzimidazoles, that suppress gastric acid secretion by specific inhibition of the enzyme system at the secretory surface of the gastricparietal cell. Because this enzyme system is regarded as the acid (proton) pump within the gastric mucosa, omeprazole has been characterized as a gastric acid-pump inhibitor, in that it blocks the final step of acid production.

INDICATIONS

GERD,heart burn & hyperacidity,reflux oesophagitis,regurgitation & flatulence,gastric & peptic ulcer.

DOSAGE & ADMINISTRATION

The usual recommended dose of Pantoprazole + Domperidone is one capsule daily before breakfast. Swallow capsule as a whole, do not chew the capsule.

CONTRAINDICATIONS

Domperidone is contraindicated in conditions associated with rise in prolactin level. Omeprazole is contraindicated in hypersensitive patients.

PRECAUTIONS

  • Domperidone can cause a rise in serum prolactin level resulting in galactorrhoea in females and less frequently gynaecomastia in males.
  • Hypertensive crisis may occur in patients with phaeochromocytoma.
  • Renal impairment or those at risk of fluid retention.
  • Monitor patients on warfarin or phenytoin therapy, reduce dose if necessary.

ADVERSE EFFECTS

Generally well tolerated. Most common side effects are somnolence,dizziness,dry mouth and blurring of vision.

PREGNANCY & LACTATON

There was no evident harm on the development of the fetus.Pantoprazole has been found to pass through the breast milk. Risks and benefits are recommended for consideration in determining the use of therapy for the mother and child.

PRESENTATION

DOMZEL-O capsules are available in 10X15ís strip pack.

CAUTION

The medical information on this site is provided as an information resource only, and is not to be used or relied on for any diagnostic or treatment purposes. This information is not intended to be patient education, does not create any patient-physician relationship, and should not be used as a substitute for professional diagnosis and treatment. Please note it is dangerous to take any medication without doctorís prescription or professional advice from a registered health practitioner. Always read the product directions before use. Do not exceed the recommended dosage. Keep all medicines away from children. Store as recommended. Please consult your health care provider, before making any healthcare decisions or for guidance about a specific medical condition. The allopathic medication and as per the law in India it must be sold by retail pharmacies holding valid trading drug license only.

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