Each DOMZEL-O capsule contains domperidone 10mg and omeprazole 20mg.
DOMZEL-O is the brand name for the anti-ulcer and antiemetic combination of domperidone and omeprazole. This combination effectively treats gastric, duodenal and peptic ulcers, Helicobacter pylori infections and dyspepsia.
Omeprazole belongs to the class of proton pump inhibitors that works by blocking the H+/K+ ATP system (proton-pump system), which controls the movement of H+ ions through it. When omeprazole binds to this proton pump system, it prevents the inward movement of H+ ions into the stomach and thereby inhibits the final step of the gastric acid formation. This drug is activated in the acidic environment only.
Domperidone improves GI peristalsis and causes prolactin release. This drug also exhibits antiemetic activities and it works by blocking the dopamine receptors. It has strong affinities for the D2 and D3 receptors and regulates nausea and vomiting.
As directed by the physician
DOMZEL-O capsule is contraindicated in patients with hypersensitivity towards omeprazole and domperidone, low amount of magnesium in the blood, liver problems, interstitial nephritis, osteoporosis and broken bone.
Adverse effects of this medicine include GI disturbances, dizziness, drowsiness, insomnia, rashes, dermatitis, vertigo and increased liver enzymes.
There are no sufficient and well-controlled studies when it comes to omeprazole and domperidone administration in pregnant women and nursing mothers. Therefore, if you are pregnant or nursing, discuss with your doctor about your condition before taking this medicine.
DOMZEL-O capsules are available in 10X15’s strip packing.
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