DOLET T Suspension

Each tablet contains:

  • Tramadol - 37.5 mg
  • Paracetamol - 325 mg


DOLET-T is a combination of Tramadol and Paracetamol. The effectiveness of Tramadol for pain relief has been shown to increase when combined with paracetamol.

Tramadol is classified as an opiate analgesic and used for management of moderate to severe pain. The analgesic actions of Tramadol are only partially reversed by naloxone, suggesting that the analgesic effects are not solely due to an opiate like action. Pharmacologically, Tramadol has been shown to be similar in its actions to tapentadol and levorphanol, indicating that is not only binds to the mu-opiate receptor but also inhibits re-uptake of norepinephrine and serotonin. It is now believed that Tramadol modules the effects of serotonin and norepinephrine to produce analgesia.

Paracetamol, also known as acetaminophen, is a medication for treatment of fever and pain. Its mechanism of action is believed to be due to inhibition of cycloxygenase (COX). The COX family of enzymes have been shown to be responsible for metabolism of arachidonic acid to prostaglandins. The drug is highly selective for COX2 and does not significantly decrease production of thromboxanes. Its analgesic and antipyretic effects are comparable to other non-steroidal anti-inflammatory agents


DDOLET-T is indicated for the treatment of moderate to severe pain. It can be used to treat both acute and chronic pain from a variety of causes. For moderate pain, its effectiveness is equivalent to morphine. The analgesic effects peak at about 3 hours after ingestion and last approximately 6-7 hours.


The adult oral dose of DOLET-T is one tablet taken every 6-8 hours. The formula is available as a tablet and is taken orally, as directed. DOLET-T can be prescribed for 2-3 weeks and re-evaluation is necessary before extending use. The formula is best taken first thing in the morning with a glass of water or with food. Patients should be advised not to chew or crush the tablet in the mouth but swallow it whole.


DOLET-T should not be administered in the following cases:

  • DOLET-T is not recommended in children less than 12 year of age.
  • DOLET-T should not be prescribed to individuals allergic to Tramadol, paracetamol or any other component present in this formula.
  • DOLET-T is contraindicated in patients with head trauma, respiratory distress or in presence of central nervous depression from any cause.
  • DOLET-T should not be used concomitantly with MAO inhibitors or within 14 days following discontinuation of these agents.


Caution should be exercised when DOLET-T is prescribed at the same time as selective serotonin receptor re-uptake inhibitors and tricyclic antidepressants because the risk of seizures is increased.

Risk of seizures may be increased when DOLET-T is prescribed to patients taking MAO inhibitors or antipsychotics.

Caution should be exercised when prescribing DOLET-T to patients with head trauma, metabolic disorders or alcohol withdrawal as the risk of seizures may be increased.

DOLET-T has the potential to cause physical and psychological dependence. In patients with a history of drug abuse or drug dependence, treatment with DOLET-T is not recommended.

DOLET-T should be used at low doses in elderly individuals as there is an increased risk of adverse effects like falls, depression and cognitive impairment.

DOLET-T should be used with great caution in individuals with liver or kidney failure.

DOLET-T should be stored at room temperature and away from the reach of children.

DOLET-T may interact with other medications. Hence, it is important to obtain a complete drug and herbal usage history from patients before prescribing the formula.

Because DOLET-T contains paracetamol, patients should be warned about acute liver failure when taken at high doses. This risk is heightened when there is frequent consumption of alcohol.


Most frequent side effects of DOLET-T include nausea, dizziness, itching, constipation, sedation and a headache. Except for constipation, these side effects are temporary. When prescribing a narcotic for pain, it is recommended that physicians also prescribe a laxative at the same time to prevent constipation, which can be severe.


DOLET-T is not recommended for women who are pregnant and those who are breast feeding. The effects of these agents on the newborn have not yet been determined and to be on the safe side, it should be avoided in this population.


DOLET- T tablets are available in a 10X10ís blister packing


The medical information on this site is provided as an information resource only, and is not to be used or relied on for any diagnostic or treatment purposes. This information is not intended to be patient education, does not create any patient-physician relationship, and should not be used as a substitute for professional diagnosis and treatment. Please note it is dangerous to take any medication without doctorís prescription or professional advice from a registered health practitioner. Always follow the instructions of physician / doctor / registered medical practitioner before using any medicine. Do not exceed the recommended dosage. Keep all medicines away from your children. Store as recommended. Please consult your health care provider, before making any healthcare decisions or for guidance about a specific medical condition. The allopathic medicine as per the law in India must be sold by retail pharmacies holding valid trading drug license only.