DOLET Suspension contains Paracetamol. Paracetamol is a pharmacological agent used to treat fever and pain. The medication is generally used for treatment of mild to moderate pain from a variety of causes. The actions of paracetamol last between 2-4 hours. At the recommended doses, Paracetamol is safe for use in both adults and children. Healthcare providers need to be aware that at high doses, it can precipitate acute liver failure. However, the drug can still be used in patients with liver disease but at much lower doses and close monitoring.
Paracetamol is thought to act by inhibiting cycloxygenase (COX). The COX family of enzymes has been shown to be responsible for metabolism of arachidonic acid to prostaglandins. The drug is highly selective for COX2 and does not significantly decrease production of thromboxanes. Its analgesic and antipyretic effects are comparable to other non-steroidal anti-inflammatory agents. The drug has little anti-inflammatory activity, unlike other common analgesics and non-steroidal anti inflammatory drugs.
DOLET suspension is indicated for the treatment of mild to moderate pain and lowering of fever. It can be used to treat both acute and chronic pain from a variety of causes. DOLET suspension is recommended for the treatment of osteoarthritis by the American College of Rheumatology. Paracetamol is also effective for low back pain, headaches, menstrual cramps, toothache, the common cold, postoperative pain and can also be used in conjunction with opiates like codeine or morphine. The analgesic effects peak at about 2 hours after ingestion and lasts approximately 4-6 hours.
The adult oral dose of DOLET suspension is 5 ml which contains 250 mg of paracetamol taken every 4-6 hours. In adults this dose may be doubled if no pain relief is obtained within 60-90 minutes. The total dose of DOLET suspension should not exceed 3,000 mg in 24 hours. DOLET suspension is available over the counter and can be consumed for 2-3 weeks without harm. Patients with chronic pain should be told to follow up with their healthcare provider if they plan to use DOLET suspension for long term use. In children less than 12 years, the dose of DOLET suspension is 10-15 mg/kg every 4-6 hours.
DOLET Suspension is contraindicated to individuals allergic to paracetamol.
Caution should be exercised when DOLET suspension is prescribed at the same time as anticonvulsants and anti-coagulants.
DOLET suspension when taken in super high doses exceeding 4,000 mg/day can results in acute liver failure. The liver injury may present with elevation in serum transaminase enzymes. This risk of liver injury is increased in people who are chronic alcoholics.
DOLET suspension can be used in patients with liver disease but the doses should be low and the patient closely monitored with serial transaminase levels.
NO dose adjustment is required when DOLET suspension is used in elderly individuals.
DOLET suspension should be stored at room temperature and away from the reach of children.
In general, DOLET suspension is very safe and has no side effects. A few individuals may develop nausea or constipation, but this is a transient. Patients should be warned that alcohol consumption should be avoided when taking DOLET suspension as this may increase the risk of liver damage. There are also reports that DOLET suspension may interact adversely with anticonvulsants and oral anticoagulants. Hence, close monitoring of the patient is required.
In general, pregnant women should avoid medications during pregnancy. DOLET suspension can be used during pregnancy and does not affect the mother or the fetus. DOLET suspension does pass through breast milk but does not adversely affect the nursing infant.
DOLET Suspension is available as a suspension. Every 5 ml contains 250 mg. The total content in each bottle is 60 ml.
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