CLINDIS CZ vaginal Softgel capsules

CLINDIS CZ vaginal Softgel capsules

Composition:

Each CLINDIS-CZ softgel capsule contains clindamycin phosphate 100mg and clotrimazole 200mg.

Description:

CLINDIS-CZ is the vaginal capsule designed for the treatment of vulvovaginal infections caused due to bacteria and fungi. Clindamycin is a potent antibacterial agent, while clotrimazole is a broad spectrum antifungal agent. This combination works by stopping the growth of bacterial and fungal cells. This combination reduces the burning and itching sensation along with the abnormal vaginal discharge.

Clindamycin is lincosamide antibiotic of semi-synthetic origin with least side effects. Clindamycin works by inhibiting the protein synthesis in the bacterial cells. This drug specifically binds to the 23S RNA subunit of 50S ribosomal subunit to block the polypeptide exit tunnel and thereby prevents the peptide chain elongation. Protein synthesis is crucial for the survival of the bacterial cells and this being blocked, leads to the reduced bacterial growth. Clindamycin is bacteriostatic in action.

Clotrimazole is an imidazole derivative with both fungicidal and fungistatic properties. This drug works by interfering with the cell wall synthesis in the fungal cells. Clotrimazole blocks the synthesis of ergosterol, which is the key constituent of fungal and protozoan cells. Clotrimazole binds to 14-a demethylase, a cytochrome P-450 enzyme that converts lanosterol to ergosterol and inhibits its activity. Blocking of the ergosterol synthesis leads to the increased membrane permeability, which eventually leads to the death of the fungal and protozoan cells.

Indications:

  • Vaginal infections
  • Vulvovaginal infections
  • Vaginal mycoses secondarily infected with bacteria

Dosage and Administration:

One capsule should be inserted in the vagina, for 3 consecutive days at the bed time. Treatment should be timed as to avoid the menstrual period.

Contraindication:

CLINDIS-CZ softgels are contraindicated in patients who are hypersensitive to clindamycin and clotrimazole. It is also contraindicated in patients with blood dyscrasias, decreased neutrophils and epileptic seizures.

Adverse effects:

Adverse effects of this medicine are stinging, erythema, burning, vesication, desquamation, burning, peeling and irritation.

Precaution:

There are no sufficient and well-controlled studies when it comes to the usage of clindamycin and clotrimazole vaginal capsules in pregnant women and nursing mothers. Therefore, if you are pregnant or nursing, discuss with your doctor about your condition before taking this medicine.

Presentation:

CLINDIS-CZ softgel capsules are available in 20X1X3's blister packing.

Disclaimer:

The medical information on this website is provided as an information resource only. The information on this website is not intended to be a substitute for professional medical advice, diagnosis or treatment. Always seek the advice of your physician or other qualified health provider or a medical practitioner with any questions you may have regarding a medical condition, or to assist in understanding any information or in applying information, that you might have come across, on this website. Please note that it dangerous to take any medication without doctor’s prescription or professional advice from a registered health practitioner. Make sure to follow the instructions of physician/doctor/ registered medical practitioner before using this medicine. Medical and health information changes constantly. Therefore, the information provided on this website should not be considered current, complete or exhaustive. Please consult your healthcare provider, before coming to any conclusions with respect to your health condition or for guidance about a specific medical condition. The allopathic medicine as per the law in India must be sold by retail pharmacies holding valid trading drug license only.

Keep the medicines out of the children’s reach. This product is to be stored as recommended. Do not exceed the recommended dosage. Do not use this information in place of a visit, consultation or advice of your healthcare providers.

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