Each CEFUDAZ-625 tablet contains cefuroxime 500mg and potassium clavulanate 125mg.
CEFUDAZ-625 is an antibiotic combination of cefuroxime and potassium clavulanate, in which the former acts as the antibiotic with a beta-lactam ring, while the latter acts as a beta-lactamase inhibitor.
Cefuroxime: Cefuroxime is a beta-lactam antibiotic that belongs to the class of second generation cephalosporins. Like other beta-lactam antibiotics, cefuroxime interferes with the transpeptidase activity during the peptidoglycan synthesis. Cefuroxime binds to the specific Penicillin Binding proteins (PBPs) located within the cell envelope of the bacteria and prevents transpeptidation reaction, which is the last and final step of the peptidoglycan synthesis. This impaired cell wall synthesis is followed by the cellular lysis.
Potassium clavulanate: Potassium clavulanate is a semi-synthetic beta-lactamase inhibitor that is derived from Streptomyces. Just like cefuroxime, potassium clavulanate also contains a beta-lactam ring which binds to the beta-lactamase enzymes present within the bacterial cell wall. This binding protects the beta-lactam antibiotics (here cefuroxime) against beta-lactamase catalysis. In conjunction with cefuroxime, potassium clavulanate protects the antibiotic activity of the former and makes it more effective against the harmful bacteria.
As directed by the physician
CEFUDAZ-625 tablets are contraindicated in patients with hypersensitivity towards cefuroxime and potassium clavulanate. It is also contraindicated in patients with Clostridium difficile infection, blood clotting disorders, liver problems and kidney diseases.
Adverse effects of this medicine are accumulation of gas, cough, muscle pain, dizziness, upset stomach, diarrhea, nausea, vomiting, skin rashes and stuffy nose.
There are no sufficient and well-controlled studies when it comes to cefuroxime and potassium clavulanate administration in pregnant women and nursing mothers. Therefore, if you are pregnant or nursing, discuss with your doctor about your condition before taking this medicine.
CEFUDAZ-625 tablets are available in 10X6’s Alu Alu packing.
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