CARDI-NRG Tablet
Ideal Supplement for Cardio Protection

Each film coated tablet contains

  • L-Carnitine - 250 mg
  • Vitamin D3 - 100 I.U.
  • Co Enzyme Q10 - 10 mg
  • Co Enzyme Q10 - 100 mg

Description

Effective supplement for cardiac insufficiency Guards mechanism of cardiac dysfunction

L-Carnitine, coenzyme Q10, magnesium, and vitamin E is an extremely effective treatment for cardiac insufficiency, as the nutrients provided cover most of the known mechanisms of cardiac dysfunction. Cardiac insufficiency (with its plethora of symptoms, including arrhythmias, pulse abnormalities, pressure on the chest, difficulty breathing, and a sense of something being wrong in the area of the heart) is a condition which, if left untreated, will result in heart attack. Although there are many causes of cardiac insufficiency (i.e., atherosclerosis, ischemia, vasospasm), the ultimate biochemical defect is an insufficient supply of cellular energy (i.e., ATP).

CARDI-NRG is a combination of the most important energy-generating nutrients. Of all the nutritional factors required for life, L-carnitine, coenzyme Q10, magnesium, and vitamin E must be ranked among the most important for optimizing mitochondrial energy production. Other nutrients are essential, to be sure, and the emphasis on CCME should not be interpreted as diminishing the cardiovascular benefits of niacin, riboflavin, pantothenic acid, thiamin, and many other nutrients and food factors.

L-Carnitine Carnitine carries fats across the inner membrane for beta-oxidation. Carnitine (the rate-determining factor in beta oxidation) increases ATP generation via its effects on beta oxidation, as well as its role in the removal of acetyl units from the mitochondria. The later process is important because accumulation of acetyl units is known to inhibit various parts of the respiratory process. Other important actions of L-carnitine include vasodilation of the blood vessels and increased ability to sustain cardiac contractions. Finally, supplemental L-carnitine has been well-documented to reduce blood and tissue lipids, which is associated with a reduced risk of developing heart disease. Lipids provide 60-80% of the metabolic energy required by the heart, which explains why such high levels of L-carnitine are stored in cardiac muscle. Moreover, interference with fatty acid oxidation can have dire consequences on myocardial function. Cognizance of L-carnitine's import has led to numerous investigations, the results of which have documented its cardiovascular benefits in both animals and humans.Carnitine is perhaps best known for its lipid-lowering activity, specifically, its ability to rapidly and markedly decrease plasma triglycerides and increase HDL cholesterol.

Coenzyme Q10 Coenzyme Q10 is the key factor in the electron transport system. Coenzyme Q10 is an integral part of the electron transport system, and hence regulates the ATP-generating capabilities. In addition to its well-known role in carrying electrons, recent studies have shown that coenzyme Q10 transports protons for the proton gradient used to drive oxidative phosphorylation. The later, of course, is required for ATP synthesis. Thus, coenzyme Q10 plays a pivotal role in all energy-generating systems. All organisms with an Electron Transport System (ETS) have an absolute requirement for coenzyme Q10. Both animal and human studies have unequivocally proven the beneficial effects of supplementary coenzyme Q10 in numerous types of heart disease, as well as hypertension and stroke.

Magnesium Magnesium is an essential cofactor for many of the enzyme systems which support energy production. Moreover, it is required for ATP stability, as ATP is synthesized as the magnesium complex. Magnesium is now recognized as a first-line medicine for the treatment of heart attacks. A study published in The Lancet, for example, reported the effects of a double-blind, randomized, placebo controlled study in 2,316 patients with suspected myocardial infarction (MI).The dose of magnesium was high (about 8.7 grams given intravenously over a 24-hour period), but the results were remarkable: magnesium reduced cardiovascular mortality by 25. The author's conclusion: "Intravenous magnesium sulfate is a simple, safe, and widely applicable treatment. Its efficacy in reducing early mortality of myocardial infarction is comparable to, but independent of, that of thrombolytic or antiplatelet therapy."

These findings have been confirmed and reconfirmed in many clinics and laboratories. Teo and colleagues, for example, in an analysis of seven clinical studies, concluded that magnesium (in doses of 5-10 grams by intravenous injection) reduced the odds of death by an astounding 55%.

Studies of magnesium have revealed it to be Nature's "calcium channel blocker; unlike its drug counterparts, however, magnesium has no toxic side effects. Another important effect of supplemental magnesium is its ability to mitigate the cardio toxic effects of catecholamines. Prielipp and associates, for example, published results of a clinical trial in which magnesium (10 mg per kg body weight per hour, or approximately 700 mg per hour for an average adult) attenuated the cardio toxic effects of epinephrine in 17 bypass patients.Interestingly, the drug captopril-an angiotensin-converting enzyme (ACE) inhibitor-has been demonstrated to work by raising intracellular magnesium.

Vitamin E Vitamin E is in the membrane where it can scavenge the free radicals generated by the electron transport system.

The fourth member of this team is vitamin E-the major lipid-soluble antioxidant. A substantial body of evidence has accumulated on vitamin E's therapeutic as well as preventive actions against disease of the heart and blood vessels. Supplemental vitamin E, for example, is known to decrease LDL oxidation, which reduces macrophage-mediated (inflammatory) damage to endothelial cells, thereby preventing the production of foam cells and plaque which are characteristic of atherosclerosis. By blocking inflammation, vitamin E acts as a primary defense against cardiovascular diseases.

Vitamin E also plays a pivotal role in the inhibition of platelet aggregation. Platelets aggregate because arachidonic acid is converted into pro-aggregatory thromboxanes; this conversion is an oxidative process responsive to vitamin E treatment. The ability of vitamin E to inhibit platelet aggregation is vitally important, as excessive, uncontrolled platelet aggregation is now acknowledged to be a primary causative factor in myocardial infarction. An ancillary mechanism involves vitamin E's ability to block redox cycling of catecholamine - the net result being a diminution in abnormal sympathetic stimulation of the heart.

Nutrient

Health Benefits

L-Carnitine

Increases ATP
Increases beta-oxidation
Decreases blood & tissue triglycerides

Coenzyme Q10-

Increases ATP, antioxidant

Magnesium

Calcium channel blocker
Increases ATP stability
Decreases catecholamine damage

Vitamin E

 Antioxidant
Decreases platelet aggregation
Decreases Thromboxane & increases prostacyclin
Decreases leucotriene-mediated inflammation

 

Indications

  • CARDI-NRG improves the contractility of the heart by exerting a positive inotropic action.
  • Helps vasodilatation of the blood vessels and increase ability to sustain cardiac contractions.
  • Magnesium is calcium channel blocker and decreases catecholamine damage.
  • Vitamin E decreases platelet aggregation, thromboxane and leukotriene-mediated inflammation.
  • Arrythmia, pulse abnormalities, vasospasm, difficulty breathing, atherosclerosis ischemia.

Dosage & Administration

One tablet a day.One tablet a day.

Contraindication

L-Carnitine should not be administered with warfarin as it increases the effect of warfarin and increases the chances of bruising and bleeding. Be sure to have your blood checked regularly.

Vitamin E is an antioxidant. There is some concern that antioxidants might decrease the effectiveness of some medications used for cancers.

Adverse effects

It can cause some mild side effects including stomach upset, loss of appetite, nausea, vomiting, and diarrhea.

Presentation

CARDI-NRG Tablets are available in 10X10s blister pack

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