Binadis Cream

Terbinafine Cream

Terbinafine

Terbinafine is a synthetic antifungal compound and is an allylamine derivative. it acts by inhibtion of squalene epoxidase in fungal cell membrane.

Indication

Fungal infections of the skin caused by dermatophytes like Trichophyton spp., Microsporum spp., Epidermophyton spp. Orally indicated in the treatment of onychomycosis caused by dermatophytes

Dosage

Adults: 250mg for a duration of 2-6 weeks in Tinea pedia, 2-4 weeks in Tinea corporis/curis, 2-4 weeks in candidiasis, 4 weeks Tinea capitis. 6-12 weeks in onychomycosis
Children: 2 yrs. and old: upto 20kg bodywieght and above): 62.5mg once a day; 20 to 40kg body weight: 125mg once a day;> 40kg bodyweight:250mg once a day

Contraindications

Hypersenstivity to terbinafine

Special Precautions

Pre-existing liver or renal impairment, irregular use or premature discontinuation carries the risk of recurrence of infection. Elderly patients, pregnancy lactation

Side effects

Gastrointestinal symptoms, skin reactions, taste disturbance, hepatbiliary dysfuction, haematological disorders

Drug Interactions

Negligible potential for inhibiting or inducing the clearance of drugs that are metabolised via cytochrome system e.g. cyclosporin, tolbutamide or oral contraceptives. Drugs that induce or inhibit microsomal enzymes may interfere with terbinafine metabolism. Terbinafine decreases caffeine clearance

Top