Ambroxol is a mucolytic agent and an active metabolite of bromhexine. Ambroxol acts to reduce the viscosity of tenacious mucus secretions by fragmentation of long mucopolysaccharide chains. This results in a productive cough which aidsexpectoration of liquefied mucoid respiratory secretions, and assists in clearing and maintaining patent bronchioles and alveoli. Ambroxol enhances the concentrations of antibiotics in pulmonary tissue thereby ensuring a more rapid recovery.
Azithromycin is an azalide antibiotic, a subclass of macrolide antibiotic. It acts by binding to the 50s ribosomal subunit of susceptible microorganisms and thus interfering with microbial protein synthesis. Azithromycin has been shown to be active against most strains in the following microorganisms, both in vitro and in clinical infections gram-positive microorganisms and gram-negative microorganisms.
Azithromycin is having higher tissue concentration and shorter duration of treatment with just once a day dose .It is highly effective against intracellular pathogens such as mycoplasma,clamydia,legionella and salmonella.
AZODIS-AX Tablet is indicated for the treatment of patients with mild to moderate infections caused by susceptible strains of the designated microorganisms in the specific conditions listed below.
Upper Respiratory Tract Infections
Lower Respiratory Tract Infections
As directed by the physician.
AZODIS-AX Tablet is contraindicated in patients with known hypersensitivity to ambroxol, azithromycin, erythromycin, or any macrolide antibiotic.
Because azithromycin is principally eliminated via the liver, caution should be exercised when azithromycin is administered to patients with severe impaired hepatic function.
Serious allergic reactions have been reported rarely in patients on azithromycin therapy. If an allergic reaction occurs, the drug should be discontinued and appropriate therapy should be instituted.
Side effects with azithromycin were mild to moderate in severity and were related to the gastrointestinal tract, e.g., nausea, vomiting, diarrhea, or abdominal pain. Rarely but potentially serious side effects were angioedema and cholestatic jaundice.
Ambroxol: The side effects on account of ambroxol include gastrointestinal side effects, skin rashes, headache, dizziness and sweating.
There are no adequate and well-controlled studies in pregnant women. Therefore AZODIS-AX Tablet should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus.
Nursing Mothers : It is not known whether AZODIS-AX Tablet is excreted in human milk. Because many drugs are excreted in human milk, caution should be exercised when AZODIS-AX is administered to a nursing woman.
AZODIS-AX tablets are available in a 10X3ís Alu Alu packing.
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