Azithromycin is an azalide antibiotic, a subclass of macrolide antibiotic. It acts by binding to the 50s ribosomal subunit of susceptible microorganisms and thus interfering with microbial protein synthesis. Azithromycin has been shown to be active against most strains in the following microorganisms, both In vitro and in clinical infections:
Gram-positive microorganisms: Staphylococcus aureus, Streptococcus agalactiae, Streptococcus pneumoniae, Streptococcus pyogenes.
Gram-negative microorganisms: Haemophilus ducreyi, Haemophilus influenzae, Moraxella catarrhalis, Neisseria gonorrhoeae, Escherichia coli.
Azithromycin is indicated for infections caused by susceptible organisms in- Upper respiratory tract infections including sinusitis, pharyngitis and tonsillitis, lower respiratory tract infections including bronchitis, acute bacterial exacerbations of chronic obstructive pulmonary disease (COPD),otitis media,skin and soft tissue infections including cellulitis, pyoderma, erysipelas, wound infections,diarrhea, shigellosis,Sexually transmitted diseases, especially in the treatment of non-gonococcal urethritis and cervicitis due to Chlamydia trachomatis,genital ulcer disease in men due to Haemophilus ducreyi (chancroid),mild or moderate typhoid due to multiple-antibacterial resistant organisms,prophylaxis against a-hemolytic streptococcal bacterial endocarditis.
As directed by the physician.
The use of azithromycin is contraindicated in patients with hypersensitivity to azithromycin,erythromycin ,any macrolide or ketolide antibiotic.
symptoms, when symptomatic therapy was discontinued, the allergic symptoms recurred soon thereafter in some patients without further azithromycin exposure. These patients required prolonged periods of observation and symptomatic treatment.
If an allergic reaction occurs, the drug should be discontinued and appropriate therapy should be instituted.
Caution should be exercised in patients with abnormal liver function, hepatitis, cholestatic jaundice, hepatic necrosis, and hepatic failure have been reported, some of which have resulted in death
Adverse effects with Azithromycin are likely to be minor: abdominal pain, rash and headache.
There are no adequate and well-controlled studies in pregnant women. Therefore AZODIS-250 should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus.
Nursing Mothers: It is not known whether AZODIS-250 is excreted in human milk. Because many drugs are excreted in human milk, caution should be exercised when AZODIS-250 is administered to a nursing woman.
AZODIS-250 tablets are available in a 10X6ís blister packing.
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