Dry skin or Xerosis, there are many complex factors that contribute to dry flaky skin. The contribution of aquaporins in keeping our skin moist and hydrated is significant. ALOTOL ADVANCE is a unique combination designed to regulate the ability to channel moisture to the areas where it is needed the most. This effect is achieved via upregulation of the key water channeling protein called Aquaporin-3.
The epidermis, the uppermost layer of the skin, is completely empty of blood vessels. Due to this, the epidermis is not obtaining nutrients from blood (like our other organs in body), instead it gets nutrients only by the water that is circulating. It is assumed that the cells are equipped with water channels; these are the pathway through which water can pass efficiently. These water channels were named as ‘aquaporins’. The skin gets moisturized and lubricated through this task of nutrient supplies through water circulation. Thus for the skin to remain at optimum level of moist and lubricated it is important that, these water channeling pathways are more in number.
There are thirteen different aquaporins (AQP0 to AQP12) that has been identified in the human body, among these only AQP 3 was identified to be present and active in the epidermis. The regulation of water flow by AQP3 plays an important role in regulating dryness, skin elasticity and skin barrier functions. So the conclusion is the moisture and lubrication of the skin is highly dependent on the increased amount of AQP3 in the skin.
ALOTOL ADVANCE is highly effective formulation of yeast amino acids, trehalose along with the three osmolyte regulators – inositol, taurine & betaine, formulated to help in increasing the number of water channels in the skin and encouraging the maintenance of a moisture, plumpness of skin by helping water to flow more effectively. ALOTOL ADVANCE regulates the cellular membrane water control &increases skin moisturisation by 30% in just 15 minutes. ALOTOL ADVANCE also helps to increase ceramide synthesis in the skin and causes more of the long-chain beneficial ceramides.
Yeast amino acids are believed to increase the production of collagen by fibroblasts in the dermis of the skin. Collagen is the main structural protein in skin that gives it its support and youthful firmness. Collagen production slows down with age and the remaining collagen bundles and fibers become disorganized and damaged. Exposure to sunlight also accelerates the loss of collagen by activating enzymes that break it down. This is what causes skin to develop wrinkles and laxity that make it look less youthful.
Trehalose is a sugar having rehydrating, water binding and antioxidant properties. Trehalose forms a gel phase as cells dehydrate which prevents disruption of internal cell organelles by effectively splinting them in position.
Apply liberally to the face, hands, legs & elbow, and massage it gently. Use after bathing and showering every day.