Effecient multi-action antifungal

Lulidex Cream
Luliconazole 1% cream

Luliconazole Cream

Description

Luliconazole is an imidazole antifungal agent with a unique structure, as the imidazole moiety is incorporated into the ketene dithioacetate structure. Luliconazole is the R-enantiomer, and has more potent antifungal activity.

Lulidex(Luliconazole) Cream, 1% contains 1% luliconazole, an azole antifungal agent, in a white cream for topical application. Luliconazole is (2E)-2-[(4R)-4-(2,4-dichlorophenyl)-1,3-dithiolan-2-ylidene]-2-imidazol-1-ylacetonitrile. The structural formula for Luliconazole is:

  • Luliconazole 1% cream is a topical antifungal agent and belongs to the azole class of antifungals
  • Luliconazole is indicated in patients 18 years or older for treatment of tinea pedis (athlete’s foot), tinea cruris (jock itch, affecting tissue surrounding and/or including the groin) and tinea corporis (ringworm)

The molecular formula is C14H9Cl2N3S2 with a molecular weight of 354.28. Luliconazole is the R-enantiomer and contains one chiral center. Luliconazole is an antifungal that belongs to the azole class. Although the exact mechanism of action against dermatophytes is unknown, luliconazole appears to inhibit ergosterol synthesis by inhibiting the enzyme lanosterol demethylase. Inhibition of this enzyme’s activity by azoles results in decreased amounts of ergosterol, a constituent of fungal cell membranes and a corresponding accumulation of lanosterol.

INDICATIONS

Lulidex(Luliconazole) cream 1%, is an azole antifungal indicated for the topical treatment of interdigital tinea pedis, tinea cruris, and tinea corporis caused by the organisms Trichophyton rubrum and Epidermophyton floccosum, in patients 18 years of age and older

DOSAGE & ADMINISTRATION

For topical use only. Not for ophthalmic, oral or intravaginal use

Interdigital Tinea Pedis:
Lulidex Cream, should be applied to the affected and immediate surrounding area(s) once a day for two weeks

Tinea Cruris and Tinea Corporis:
Lulidex Cream, should be applied to the affected skin and immediate surrounding area(s) once a day for one week.

CONTRAINDICATIONS

None

DRUG INTERACTIONS

The potential of luliconazole to inhibit cytochrome P-450 (CYP) enzymes 1A2, 2C9, 2C19, 2D6, and 3A4 was evaluated in vitro. Based on in vitro assessment, luliconazole at therapeutic doses, particularly when applied to patients with moderate to severe tinea cruris, may inhibit the activity of CYP2C19 and CYP3A4. However, no in vivo drug interaction trials have been conducted to evaluate the effect of luliconazole on other drugs that are substrates of CYP2C19 and CYP3A4. Luliconazole is not expected to inhibit CYPs 1A2, 2C9 and 2D6 based on in vitro assessment. The induction potential of luliconazole on CYP enzymes has not been evaluated.

PRESENTATION

Lulidex Cream is available in a pack of 20g tube

CAUTION

The medical information on this site is provided as an information resource only, and is not to be used or relied on for any diagnostic or treatment purposes. This information is not intended to be patient education, does not create any patient-physician relationship, and should not be used as a substitute for professional diagnosis and treatment. Please note it is dangerous to take any medication without doctor’s prescription or professional advice from a registered health practitioner. Always follow the instructions of physician / doctor / registered medical practitioner before using any medicine. Do not exceed the recommended dosage. Keep all medicines away from your children. Store as recommended. Please consult your health care provider, before making any healthcare decisions or for guidance about a specific medical condition. The allopathic medicine as per the law in India must be sold by retail pharmacies holding valid trading drug license only.

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